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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

1,3-PROPANE SULTONE
(Group 2B)

For definition of Groups, see Preamble Evaluation.

VOL.: 71 (1999) (p. 1095)

CAS No.: 1120-71-4
Chem. Abstr. Name: 1,2-Oxathiolane, 2,2-dioxide

5. Summary of Data Reported and Evaluation

5.1 Exposure data

1,3-Propane sultone has been used as an intermediate in the production of a variety of chemical products.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

1,3-Propane sultone is carcinogenic in rats by all routes of administration (oral, dermal, intravenous, subcutaneous or prenatal), producing tumours at various sites including the brain and mammary gland. In mice, it was carcinogenic after skin application and subcutaneous injection producing local tumours.

5.4 Other relevant data

1,3-Propane sultone is mutagenic in bacteria. It is positive for many genetic activity end-points in vitro in rodent and human cells. 1,3-Propane sultone induces DNA strand breaks in vivo in rat brain cells.

5.5 Evaluation

No epidemiological data relevant to the carcinogenicity of 1,3-propane sultone were available.

There is sufficient evidence in experimental animals for the carcinogenicity of 1,3-propane sultone.

Overall evaluation

1,3-Propane sultone is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluations: Vol. 4 (1974); Suppl. 7 (1987)

Synonyms


Last updated: 13 April 1999





















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       Toxicological Abbreviations