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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

1,1,2-TRICHLOROETHANE
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 71 (1999) (p. 1153)

CAS No.: 79-00-5
Chem. Abstr. Name: 1,1,2-Trichloroethane

5. Summary of Data Reported and Evaluation

5.1 Exposure data

1,2-Trichloroethane is used in the manufacture of vinylidene chloride. It has been detected in
ground-, drinking-, waste- and ambient water and ambient air.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

1,1,2-Trichloroethane was tested for carcinogenicity in a two-year study in male and female B6C3F1 mice and Osborne-Mendel rats by oral administration and in Sprague-Dawley rats by subcutaneous injection. In the study by oral administration, 1,1,2-trichloroethane produced hepatocellular neoplasms and adrenal phaeochromocytomas in mice of each sex but did not significantly increase the proportion of rats with neoplasms at any site relative to untreated controls. In the study in rats by subcutaneous injection, 1,1,2-trichloroethane did not increase the incidence of neoplasms.

5.4 Other relevant data

1,1,2-Trichloroethane bound to DNA, RNA and protein and caused strong S-phase induction but not unscheduled DNA synthesis in rodents in vivo. It induced DNA damage and micronuclei in human lymphocytes and cell transformation in BALB/c-3T3 cells in vitro. 1,1,2-Trichloroethane caused chromosomal malsegregation in fungi and showed some evidence of mutagenicity in bacteria.

5.5 Evaluation

No epidemiological data relevant to the carcinogenicity of 1,1,2-trichloroethane were available.

There is limited evidence in experimental animals for the carcinogenicity of 1,1,2-trichloroethane.

Overall evaluation

1,1,2-Trichloroethane is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluations: Vol. 20 (1979); Suppl. 7 (1987); Vol. 52 (1991)

Synonym


Last updated: 13 April 1999





















    See Also:
       Toxicological Abbreviations
       Trichloroethane, 1,1,2- (IARC Summary & Evaluation, Volume 52, 1991)