For definition of Groups, see Preamble Evaluation.
VOL.: 77 (2000) (p. 177)CAS No.:
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Cinnamyl anthranilate was used as a synthetic flavouring and fragrance agent. It has not been commercially available since 1985. No information was available on its occurrence in the workplace or in the environment.
5.2 Human carcinogenicity data
No data were available to the Working Group.
5.3 Animal carcinogenicity data
Cinnamyl anthranilate was tested for carcinogenicity in one experiment in mice and in one experiment in rats by oral administration in the diet. In mice, a dose-related increase in the incidence of hepatocellular tumours was found, but there was no increased incidence of tumours in rats. In a mouse lung tumour bioassay, an increased multiplicity of lung tumours was found.
5.4 Other relevant data
Cinnamyl anthranilate is metabolized by hydrolysis to anthranilic acid and cinnamyl alcohol, which is oxidized to benzoic acid. In mice, but not in rats or humans, the hydrolysis is saturated at high doses, leading to excretion of unchanged cinnamyl anthranilate in the urine.
Cinnamyl anthranilate has the characteristic effects of a peroxisome proliferator on mouse liver, increasing the activity of peroxisomal fatty acid-metabolizing enzymes and microsomal CYP4A and increasing hepatocellular proliferation. These effects are mediated by the intact ester, and were not seen after administration of the hydrolysis products, cinnamyl alcohol and anthranilic acid. The corresponding effects on rat liver were very much weaker. No relevant data from humans were available.
The only standard genotoxicity assay in which cinnamyl anthranilate was active was the mouse lymphoma mutation assay.
No epidemiological data relevant to the carcinogenicity of cinnamyl anthranilate were available.
There is limited evidence in experimental animals for the carcinogenicity of cinnamyl anthranilate.
Cinnamyl anthranilate is not classifiable as to its carcinogenicity to humans (Group 3).For definition of the italicized terms, see Preamble Evaluation.
Previous evaluations: Vol. 16 (1978); Vol. 31 (1983); Suppl. 7 (1987) (p. 60)
See Also: Toxicological Abbreviations Cinnamyl anthranilate (WHO Food Additives Series 16) CINNAMYL ANTHRANILATE (JECFA Evaluation) Cinnamyl Anthranilate (IARC Summary & Evaluation, Volume 16, 1978) Cinnamyl Anthranilate (IARC Summary & Evaluation, Volume 31, 1983)