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0 METHYL ISOCYANATE
ICSC: 0004
Peer-Review Status: 27.11.2003 Validated
Isocyanatomethane
Isocyanic acid, methyl ester 
CAS #: 624-83-9 RTECS #: NQ9450000
UN #: 2480
EC #: 615-001-00-7
EINECS #: 210-866-3
    Formula: CH3NCO
Molecular mass: 57.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking. NO contact with water, acids, bases or oxidizing agents.  Use alcohol-resistant foam, dry sand, powder, carbon dioxide. NO hydrous agents. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position. 
 
EXPOSURE   AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Laboured breathing. Shortness of breath. Sore throat. Vomiting.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain. Burning sensation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Pain. Redness. Loss of vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Burning sensation. Shock or collapse.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize spilled liquid with with caustic soda. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.  Special material. 
EC Classification
Symbol: F+, T+; R: 12-24/25-26-37/38-41-42/43-63; S: (1/2)-26-27/28-36/37/39-45-63 
UN Classification
UN Hazard Class: 6.1; UN Subsidiary Risks: 3; UN Pack Group: I 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S2480.
NFPA Code: H4; F3; R2; W. 
Fireproof. See Chemical Dangers. Cool. Dry. Store only if stabilized. 

IMPORTANT DATA
Physical State; Appearance
VOLATILE COLOURLESS LIQUID WITH PUNGENT ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. The vapour mixes well with air, explosive mixtures are easily formed. 

Chemical dangers
The substance polymerizes when pure. The substance may polymerize due to heating and under the influence of metals and catalysts. Decomposes on contact with water. Decomposes rapidly on contact with acids or bases. This produces toxic gases of of hydrogen cyanide, nitrogen oxides and carbon monoxide. Attacks some forms of plastic, rubber and coatings. 

Occupational exposure limits
TLV:.
MAK: 0.01 ppm, 0.024 mg/m³; Peak limitation category: I(1); Pregnancy risk group: D; Sensitization of skin (SH); (DFG 2003). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is severely irritating to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of of the vapour may cause lung oedema. See Notes. Inhalation may cause asthma-like reactions. Exposure could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the respiratory tract. Causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 39°C
Melting point: -80°C
Relative density (water = 1): 0.96
Solubility in water at 20°C: reaction
Vapour pressure, kPa at 20°C: 54
Relative vapour density (air = 1): 2
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.44
Flash point: -7°C c.c.
Auto-ignition temperature: 535°C
Explosive limits, vol% in air: 5.3-26 
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. 

NOTES
Reacts violently with fire extinguishing agents such as water and hydrated agents.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home.
Card has been partly updated in October 2004.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations