IPCS INCHEM Home
1,4-DIOXANEICSC: 0041
November 2008
CAS #: 123-91-11,4-Diethylene dioxide
Dioxane
para-Dioxane
UN #: 1165
EINECS #: 204-661-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.  Vapour/air mixtures are explosive. Risk of fire and explosion on contact with incompatible substances. See Chemical Dangers.  NO open flames, NO sparks and NO smoking. NO contact with strong oxidizing agents. NO contact with hot surfaces.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.  Use powder, alcohol-resistant foam, water spray, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT GENERATION OF MISTS!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Cough. Sore throat. Nausea. Dizziness. Headache. Drowsiness. Vomiting. Unconsciousness. Abdominal pain.  Use ventilation (not if powder), local exhaust or breathing protection.  Fresh air, rest. Refer immediately for medical attention. 
Skin MAY BE ABSORBED!  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Seek medical attention if you feel unwell. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable air tight containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. 

According to UN GHS Criteria

flam;flameexcl mark;warncancer;health haz
DANGER
Highly flammable liquid and vapour
Causes eye irritation
May cause respiratory irritation
Suspected of causing cancer
May be harmful if swallowed and enters airways 

Transportation
UN Classification
UN Hazard Class: 3; UN Pack Group: II 

STORAGE
Fireproof. Separated from strong oxidants, strong acids and incompatible materials. Cool. Dry. Well closed. Keep in the dark. Store only if stabilized. Store in an area without drain or sewer access. 
PACKAGING
Airtight. 
1,4-DIOXANE ICSC: 0041
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
The substance can form explosive peroxides on exposure to air. Reacts with oxidants and strong acids. Reacts violently with some catalysts. 

Formula: C4H8O2
Molecular mass: 88.1
Boiling point: 101°C
Melting point: 12°C
Relative density (water = 1): 1.03
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 3.9
Relative vapour density (air = 1): 3.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.08
Flash point: 12°C c.c.
Auto-ignition temperature: 180°C
Explosive limits, vol% in air: 2-22.0
Octanol/water partition coefficient as log Pow: -0.27
Viscosity: 1.17 mm²/s at 25°C 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and through the skin. 

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Exposure at high levels could cause lowering of consciousness. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C , on spraying or dispersing much faster. 

Effects of long-term or repeated exposure
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system, kidneys and liver. This substance is possibly carcinogenic to humans. 


Occupational exposure limits
TLV: 20 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: 73 mg/m3, 20 ppm; peak limitation category: I(2); skin absorption (H); carcinogen category: 4; pregnancy risk group: C.
EU-OEL: 73 mg/m3, 20 ppm as TWA 

ENVIRONMENT
 

NOTES
Refer for medical attention if breathing difficulties and/or fever develop.
Check for peroxides prior to distillation; eliminate if found. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: F, Xn; R: 11-19-36/37-40-66; S: (2)-9-16-36/37-46; Note: D 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.
    See Also:
       Toxicological Abbreviations