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EPICHLOROHYDRIN
ICSC: 0043
Peer-Review Status: 24.11.2003 Validated
1-Chloro-2,3-epoxypropane
gamma-Chloropropylene oxide
2-(Chloromethyl)oxirane 
CAS #: 106-89-8 RTECS #: TX4900000
UN #: 2023
EC #: 603-026-00-6
EINECS #: 203-439-8
    Formula: C3H5ClO
Molecular mass: 92.5

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION Above 31°C explosive vapour/air mixtures may be formed.  Above 31°C use a closed system, ventilation and explosion-proof electrical equipment.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Burning sensation. Cough. Sore throat. Headache. Laboured breathing. Nausea. Shortness of breath. Vomiting. Tremor. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Serious skin burns. Burning sensation. Pain. Blisters.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Pain. Redness. Loss of vision. Severe deep burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Burning sensation in the throat and chest. Diarrhoea. Headache. Nausea. Sore throat. Vomiting. Shock or collapse.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 45-10-23/24/25-34-43; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Subsidiary Risks: 3; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S2023.
NFPA Code: H3; F3; R2. 
Fireproof. Separated from strong oxidants, acids, bases, aluminium, zinc, amines and food and feedstuffs. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
The substance polymerizes due to heating or under the influence of strong acids and bases. On combustion, forms toxic and corrosive fumes of hydrogen chloride (see ICSC 0163) and chlorine (see ICSC 0126). Reacts violently with strong oxidants. Reacts violently with aluminium, zinc, alcohols, phenols, amines (especially aniline) and organic acids. This generates fire and explosion hazard. Attacks steel in the presence of water. 

Occupational exposure limits
TLV: 0.5ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2003).
MAK: Carcinogen category: 2; Germ cell mutagen group: 3B; Skin absorption (H); Sensitization of skin (SH); (DFG 2003). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of of the vapour may cause lung oedema. See Notes. Inhalation of the vapour may cause asthma-like reactions. The substance may cause effects on the central nervous system, kidneys and liver. This may result in convulsions, kidney impairment and liver impairment. Exposure at high levels could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys, liver and lungs. This may result in impaired functions. This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 116°C
Melting point: -48°C
See Notes.
Relative density (water = 1): 1.2
Solubility in water, g/100ml at 20°C: 6
Vapour pressure, kPa at 20°C: 1.6
Relative vapour density (air = 1): 3.2
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 31°C c.c.
Auto-ignition temperature: 385°C
Explosive limits, vol% in air: 3.8-21
Octanol/water partition coefficient as log Pow: 0.26  
The substance is harmful to aquatic organisms. 

NOTES
Other melting points: -25.6 °C and -57°C.
Depending on the degree of exposure, periodic medical examination is indicated.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Epichlorohydrin (EHC 33, 1984)
       Epichlorohydrin (HSG 8, 1987)
       Epichlorohydrin (IARC Summary & Evaluation, Volume 71, 1999)