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DIAZINONICSC: 0137
O,O-Diethyl-O-(2-isopropyl-6-methylpyrimidin-4-yl) phosphorothioate
Phosphorothioic acid O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester
October 2004
CAS #: 333-41-5
UN #: 3018
EC Number: 206-373-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  Risk of fire and explosion if formulations contain flammable/explosive solvents.  NO open flames.    Use water spray, powder, foam, carbon dioxide.   

 AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS PREVENTION FIRST AID
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Laboured breathing. Nausea. Vomiting. Dizziness. Convulsions. Unconsciousness.  Use ventilation, local exhaust or breathing protection. Avoid inhalation of mist.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain. See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Provision to contain effluent from fire extinguishing. Separated from strong oxidants, strong acids, bases and food and feedstuffs. Keep in a well-ventilated room. 
PACKAGING
Do not transport with food and feedstuffs.
Severe marine pollutant. 
DIAZINON ICSC: 0137
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
OILY COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. TECHNICAL-GRADE PRODUCT: PALE YELLOW-TO-DARK BROWN. 

Physical dangers
 

Chemical dangers
Decomposes above 120°C . This produces toxic fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. Reacts with strong acids and alkalis with possible formation of highly toxic tetraethyl thiopyrophosphates. Reacts with strong oxidants. 

Formula: C12H21N2O3PS / (CH3)2CHC4N2H(CH3)OPS(OC2H5)2
Molecular mass: 304.4
Decomposes at 120°C
Relative density (water = 1): 1.1
Solubility in water, g/100ml at 20°C: 0.006
Vapour pressure at 20°C: negligible
Octanol/water partition coefficient as log Pow: 3.11  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Effects of short-term exposure
The substance is mildly irritating to the eyes and skin. The substance may cause effects on the nervous system. This may result in convulsions and respiratory depression. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.01 mg/m3, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued.
MAK: (inhalable fraction): 0.1 mg/m3; peak limitation category: II(2); skin absorption (H); pregnancy risk group: C 

ENVIRONMENT
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: Xn, N; R: 22-50/53; S: (2)-24/25-60-61 

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    See Also:
       Toxicological Abbreviations
       Diazinon (EHC 198, 1998)
       Diazinon (FAO Meeting Report PL/1965/10/1)
       Diazinon (FAO/PL:CP/15)
       Diazinon (FAO/PL:1967/M/11/1)
       Diazinon (FAO/PL:1968/M/9/1)
       Diazinon (AGP:1970/M/12/1)
       Diazinon (WHO Pesticide Residues Series 5)
       Diazinon (Pesticide residues in food: 1979 evaluations)
       Diazinon (Pesticide residues in food: 1993 evaluations Part II Toxicology)
       Diazinon (JMPR Evaluations 2001 Part II Toxicological)