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HEXAMETHYLPHOSPHORIC TRIAMIDE
ICSC: 0162
Peer-Review Status: 27.10.1994 Validated
Hexamethylphosphoramide
Hexamethylphosphamide
HMPA 
CAS #: 680-31-9 RTECS #: TD0875000
EC #: 015-106-00-2
EINECS #: 211-653-8
    Formula: C6H18N3OP / {(CH3)2N}3P(O)
Molecular mass: 179.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation   Use ventilation, local exhaust or breathing protection.  Refer for medical attention. 
Skin MAY BE ABSORBED!  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear safety spectacles or face shield.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: T; R: 45-46; S: 53-45 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Ventilation along the floor. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS MOBILE LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including phosphorus oxides and nitrogen oxides. 

Occupational exposure limits
TLV: A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: Carcinogen category: 2; Germ cell mutagen group: 2; Skin absorption (H); (DFG 2009). 

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of short-term exposure
The substance may cause effects on the lungs, kidneys and central nervous system. This may result in impaired functions and depression. 

Effects of long-term or repeated exposure
The substance may have effects on the respiratory tract, kidneys and bone marrow. This substance is possibly carcinogenic to humans. May cause genetic damage in humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 232°C
Melting point: 5-7°C
Relative density (water = 1): 1.03
Solubility in water: very good
Vapour pressure, Pa at 20°C: 4
Relative vapour density (air = 1): 6.18
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 105°C 
 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Hexametapol is a trade name.
Card has been partly updated in April 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations