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HEXAMETHYLPHOSPHORIC TRIAMIDEICSC: 0162
April 2017
CAS #: 680-31-9Hexamethylphosphoramide
Hexamethylphosphamide
HMPA
EINECS #: 211-653-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, powder, alcohol-resistant foam, carbon dioxide.   

 AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation   Use ventilation, local exhaust or breathing protection.  Refer for medical attention. 
Skin MAY BE ABSORBED!  Protective gloves. Protective clothing.  Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear safety spectacles or face shield.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

cancer;health haz
DANGER
Suspected of causing cancer
May cause genetic defects 

Transportation
UN Classification
 

STORAGE
Ventilation along the floor. Separated from acids and oxidants. 
PACKAGING
 
HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS MOBILE LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. Reacts with acids and oxidants. This produces toxic fumes including phosphorus oxides and nitrogen oxides. 

Formula: C6H18N3OP / {(CH3)2N}3P(O)
Molecular mass: 179.2
Boiling point: 232°C
Melting point: 7,2 C°C
Relative density (water = 1): 1.03
Solubility in water: very good
Vapour pressure, Pa at 20°C: 4
Relative vapour density (air = 1): 6.18
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 105°C 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Effects of short-term exposure
Exposure to high concentrations could cause effects on the nervous system, kidneys and respiratory tract. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of long-term or repeated exposure
The substance may have effects on the respiratory tract, kidneys and testes. This substance is possibly carcinogenic to humans. May cause genetic damage in humans. 


Occupational exposure limits
TLV: (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: skin absorption (H); carcinogen category: 2; germ cell mutagen group: 2 

ENVIRONMENT
 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
See ICSC 0695 Formaldehyde. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T; R: 45-46; S: 53-45 

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    See Also:
       Toxicological Abbreviations