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ISOPHORONE
ICSC: 0169
Peer-Review Status: 04.10.2000 Validated
1,1,3-Trimethyl-3-cyclohexene-5-one
3,5,5-Trimethylcyclohex-2-enone
Isoacetophorone 
CAS #: 78-59-1 RTECS #: GW7700000
EC #: 606-012-00-8
EINECS #: 201-126-0
    Formula: C9H14O
Molecular mass: 138.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION Above 84°C explosive vapour/air mixtures may be formed.  Above 84°C use a closed system and ventilation.   
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Burning sensation. Sore throat. Cough. Dizziness. Headache. Nausea. Shortness of breath.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness. Pain. Blurred vision.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: Xn; R: 21/22-36/37-40; S: (2)-13-23-36/37/39-46 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F2; R0.  Separated from strong oxidants, strong bases and amines. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Reacts with strong oxidants, strong bases and amines. 

Occupational exposure limits
TLV: 5ppm (ceiling value); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: 2 ppm, 11 mg/m³; Carcinogen category: 3B; Peak limitation category: I(2); Pregnancy risk group: C; (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance and the vapour are irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. 

Effects of long-term or repeated exposure
 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 215°C
Melting point: -8°C
Relative density (water = 1): 0.92
Solubility in water, g/100ml at 25°C: 1.2
Vapour pressure, Pa at 20°C: 40
Relative vapour density (air = 1): 4.8
Flash point: 84°C c.c.
Auto-ignition temperature: 460°C
Explosive limits, vol% in air: 0.8-3.8
Octanol/water partition coefficient as log Pow: 1.67  
 

NOTES
The occupational exposure limit value should not be exceeded during any part of the working exposure.
Card has been partly updated in April 2005.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Isophorone (EHC 174, 1995)
       Isophorone (HSG 91, 1995)
       ISOPHORONE (JECFA Evaluation)