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ISOPROPYL GLYCIDYL ETHER
ICSC: 0171
Peer-Review Status: 25.11.1998 Validated
1,2-Epoxy-3-isopropoxypropane
IGE
(Isopropoxymethyl)oxirane 
CAS #: 4016-14-2 RTECS #: TZ3500000
UN #: 1993
EINECS #: 223-672-9
    Formula: C6H12O2
Molecular mass: 116.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Flammable.  NO open flames, NO sparks and NO smoking.  Use powder, AFFF, foam, carbon dioxide. 
EXPLOSION Above 33°C explosive vapour/air mixtures may be formed.  Above 33°C use a closed system, ventilation and explosion-proof electrical equipment.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Burning sensation. Cough. Dizziness. Headache. Laboured breathing. Shortness of breath. Sore throat. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin Redness. Pain.  Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness. Pain.  Wear safety spectacles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.   
EC Classification
 
UN Classification
UN Hazard Class: 3; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30GF1-III.  Fireproof. Separated from strong oxidants and acids. Cool. Dry. Keep in the dark. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID. 

Physical dangers
No data. 

Chemical dangers
The substance can presumably form explosive peroxides upon exposure to air or light. Reacts violently with strong oxidants, amines and acids. 

Occupational exposure limits
TLV: 50 ppm as TWA; 75 ppm as STEL; (ACGIH 2004).
MAK: Carcinogen category: 3B; (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. Inhalation of of the vapour may cause lung oedema. See Notes. The substance may cause effects on the central nervous system. Exposure above the OEL could cause lowering of consciousness. 

Effects of long-term or repeated exposure
 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 137°C
Relative density (water = 1): 0.92
Solubility in water, g/100ml: 19
Vapour pressure, kPa at 25°C: 1.25
Relative vapour density (air = 1): 4.15
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.04
Flash point: 33°C c.c.
Explosive limits, vol% in air: see Notes
Octanol/water partition coefficient as log Pow: 0.5  
 

NOTES
Explosive limits are unknown in literature, although the substance is combustible and has a flash point < 61°C.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation is therefore essential.
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
Check for peroxides prior to distillation; eliminate if found.
Card has been partly updated in April 2005.
See sections Occupational Exposure Limits, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations