IPCS INCHEM Home
PROPOXURICSC: 0191
April 2017
CAS #: 114-26-12-Isopropoxyphenyl methylcarbamate
Phenol, 2-(1-methylethoxy)-,methylcarbamate
2-(1-Methylethoxy)phenyl methylcarbamate
PHC
UN #: 2757
EINECS #: 204-043-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible under specific conditions. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, foam, powder, carbon dioxide.   

 PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Blurred vision. Dizziness. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Laboured breathing. Weakness. Headache. Abdominal cramps. Diarrhoea. Nausea. Vomiting. Muscle twitching. Convulsions. Unconsciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention. See Notes. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear safety spectacles or eye protection in combination with breathing protection if powder.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

skull;toxiccancer;health hazenviro;aqua
DANGER
Fatal if swallowed
Toxic if inhaled
Suspected of causing cancer
Causes damage to nervous system
Causes damage to the nervous system through prolonged or repeated exposure
Very toxic to aquatic life with long lasting effects 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 

STORAGE
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Keep in a well-ventilated room. Store only in original container. Store in an area without drain or sewer access. 
PACKAGING
Do not transport with food and feedstuffs.
Marine pollutant. 
PROPOXUR ICSC: 0191
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including methyl isocyanate and nitrogen oxides. 

Formula: C11H15NO3
Molecular mass: 209.2
Decomposes: see Notes.
Melting point: 91°C
Density (at 20°C): 1.1 g/cm³
Solubility in water, g/100ml at 20°C: 0.2 (poor)
Vapour pressure, Pa at 20°C: 0.001
Octanol/water partition coefficient as log Pow: 1.52  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance may cause effects on the nervous system by a cholinesterase inhibiting effect. This may result in convulsions and respiratory depression. Exposure could cause death. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. Tumours have been detected in experimental animals but may not be relevant to humans. 


Occupational exposure limits
TLV: 0.5 mg/m3, ppm, as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.
MAK: (inhalable fraction): 2 mg/m3; peak limitation category: II(8) 

ENVIRONMENT
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to mammals, birds, soil organisms and bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Decomposition of compound starts at 220°C.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T, N; R: 25-50/53; S: (1/2)-37-45-60-61 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.
    See Also:
       Toxicological Abbreviations
       Propoxur (WHO Pesticide Residues Series 3)
       Propoxur (Pesticide residues in food: 1981 evaluations)
       Propoxur (Pesticide residues in food: 1983 evaluations)
       Propoxur (Pesticide residues in food: 1989 evaluations Part II Toxicology)