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N,N-DIMETHYLACETAMIDE
ICSC: 0259
Peer-Review Status: 11.10.2006 Validated
Acetic acid dimethylamide
Dimethylacetamide 
CAS #: 127-19-5 RTECS #: AB7700000
EC #: 616-011-00-4
EINECS #: 204-826-4
    Formula: C4H9NO / CH3CON(CH3)2
Molecular mass: 87.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use powder, alcohol-resistant foam, water spray, carbon dioxide. 
EXPLOSION Above 70°C explosive vapour/air mixtures may be formed.  Above 63°C use a closed system, ventilation and explosion-proof electrical equipment.   
 
EXPOSURE   STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!   
Inhalation Headache. Nausea.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear face shield.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Seek medical attention if you feel unwell. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Note: E; Symbol: T; R: 61-20/21; S: 53-45 
UN Classification
 
GHS Classification
Signal: Danger
Causes damage to liver through prolonged or repeated exposure 
excl mark;warnenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F2; R0.  Ventilation along the floor. Separated from strong oxidants. 

IMPORTANT DATA
Physical State; Appearance
OILY COLOURLESS LIQUID WITH PUNGENT ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes. Reacts with strong oxidants. 

Occupational exposure limits
TLV: 10ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2006).
MAK: 10 ppm, 36 mg/m³; Peak limitation category: II(2); Pregnancy risk group: C; Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of short-term exposure
 

Effects of long-term or repeated exposure
The substance may have effects on the liver. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 165°C
Melting point: -20°C
Relative density (water = 1): 0.94
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 0.33
Relative vapour density (air = 1): 3.01
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 63°C c.c.
Auto-ignition temperature: 490°C
Explosive limits, vol% in air: 1.8 - 11.5
Octanol/water partition coefficient as log Pow: -0.77  
 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
No odour warning if toxic concentrations are present. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations