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4-NITROANILINEICSC: 0308
December 2001
CAS #: 100-01-6p-Nitroaniline
1-Amino-4-nitrobenzene
C.I. 37035
UN #: 1661
EINECS #: 202-810-1

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Many reactions may cause fire or explosion.  Finely dispersed particles form explosive mixtures in air.  NO open flames. NO contact with combustible substances.  Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.  Use water spray, powder, foam, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. 

 PREVENT DISPERSION OF DUST!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Blue lips, fingernails and skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Laboured breathing. Unconsciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 

STORAGE
Separated from strong acids, strong oxidants, combustible substances, reducing agents and food and feedstuffs. Dry. 
PACKAGING
Do not transport with food and feedstuffs. 
4-NITROANILINE ICSC: 0308
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW CRYSTALS OR POWDER. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
May explode on heating. On combustion, forms toxic fumes of nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents. Reacts with organic materials in the presence of moisture. This generates fire hazard. 

Formula: C6H6N2O2
Molecular mass: 138.1
Boiling point: 332°C
Melting point: 148°C
Density: 1.4 g/cm³
Solubility in water, g/100ml at 18.5°C: 0.08
Vapour pressure, Pa at 20°C: 0.2
Relative vapour density (air = 1): 4.8
Flash point: 199°C
Octanol/water partition coefficient as log Pow: 2.66  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Effects of short-term exposure
The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C , on spraying or dispersing much faster. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin. See Notes. 


Occupational exposure limits
TLV: 3 mg/m3, ppm, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued.
MAK: skin absorption (H); carcinogen category: 3A 

ENVIRONMENT
The substance is harmful to aquatic organisms. 

NOTES
Depending on the degree of exposure, periodic medical examination is indicated.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Also consult ICSC 0306 2-Nitroaniline, and ICSC 0307 3-Nitroaniline. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T; R: 23/24/25-33-52/53; S: (1/2)-28-36/37-45-61; Note: C 

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       Toxicological Abbreviations