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4-NITROANILINE
ICSC: 0308
Peer-Review Status: 03.12.2001 Validated
p-Nitroaniline
1-Amino-4-nitrobenzene
C.I. 37035 
CAS #: 100-01-6 RTECS #: BY7000000
UN #: 1661
EC #: 612-012-00-9
EINECS #: 202-810-1
    Formula: C6H6N2O2
Molecular mass: 138.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Many reactions may cause fire or explosion.  NO open flames. NO contact with combustible substances.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.  In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. 
 
EXPOSURE   PREVENT DISPERSION OF DUST!   
Inhalation Blue lips, fingernails and skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Laboured breathing. Unconciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 23/24/25-33-52/53; S: (1/2)-28-36/37-45-61; Note: C 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61G12B.
NFPA Code: H3; F1; R2. 
Separated from strong acids, strong oxidants, combustible substances, reducing agents and food and feedstuffs. Dry. 

IMPORTANT DATA
Physical State; Appearance
YELLOW CRYSTALS OR POWDER. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
May explode on heating. On combustion, forms toxic fumes of nitrogen oxides. Reacts with strong acids, strong oxidants and strong reducing agents. Reacts with organic materials in the presence of moisture. This generates fire hazard. 

Occupational exposure limits
TLV: 3mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005).
MAK: Carcinogen category: 3A; Skin absorption (H); (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C ; on spraying or dispersing much faster. 

Effects of short-term exposure
The substance is mildly irritating to the eyes. The substance may cause effects on the blood. This may result in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in formation of methaemoglobin. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 332°C
Melting point: 148°C
Density: 1.4 g/cm³
Solubility in water, g/100ml at 18.5°C: 0.08
Vapour pressure, Pa at 20°C: 0.2
Relative vapour density (air = 1): 4.8
Flash point: 199°C
Octanol/water partition coefficient as log Pow: 2.66  
The substance is harmful to aquatic organisms. 

NOTES
Depending on the degree of exposure, periodic medical examination is indicated.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Also consult ICSC 0306 2-Nitroaniline, and ICSC 0307 3-Nitroaniline. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations