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PROPIONITRILE
ICSC: 0320
Peer-Review Status: 09.06.2011 Validated
Propanenitrile
Ethyl cyanide
Cyanoethane 
CAS #: 107-12-0 RTECS #: UF9625000
UN #: 2404
EINECS #: 203-464-4
    Formula: C3H5N / CH3CH2CN
Molecular mass: 55.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.  NO open flames, NO sparks and NO smoking. NO contact with hot surfaces or strong oxidizing agents.  Use powder, foam, carbon dioxide. Water may be ineffective. 
EXPLOSION Vapour/air mixtures are explosive. Heating will cause rise in pressure with risk of bursting. Risk of fire and explosion on contact with strong oxidants.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   STRICT HYGIENE!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Headache. Sore throat. Chest tightness. Shortness of breath. Nausea. Vomiting. Lethargy. Unconciousness. Respiratory and cardiac arrest. Symptoms may be delayed.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. See Notes. 
Skin EASILY ABSORBED! Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Consult an expert! Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
UN Hazard Class: 3; UN Subsidiary Risks: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Highly flammable liquid and vapour
Fatal if swallowed, in contact with skin or if inhaled
May cause drowsiness or dizziness
Causes skin and eye irritation
May cause respiratory irritation
May be harmful if swallowed and enters airways 
flam;flameskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H4; F3; R1.  Fireproof. Keep in a well-ventilated room. Separated from strong oxidants, acids and food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour mixes well with air, explosive mixtures are easily formed. The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts with acids, steam and warm water. This produces toxic and flammable hydrogen cyanide. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK (not established):.
EU OEL ( selected):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is moderately irritating to the eyes and skin. The vapour is irritating to the upper respiratory tract. The substance may cause effects on the cellular respiration. This may result in metabolic acidosis, central nervous system depression, cardiac disorders and death. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia. Ingestion may cause effects on the gastrointestinal tract. This may result in ulceration. The substance may have effects on the kidneys, liver and thyroid. This may result in impaired functions. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 97°C
Melting point: -92°C
Relative density (water = 1): 0.78
Solubility in water, g/100ml at 20°C: 10 (good)
Vapour pressure, kPa at 20°C: 5.2
Relative vapour density (air = 1): 1.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 2°C c.c.
Explosive limits, vol% in air: 3.1-?
Octanol/water partition coefficient as log Pow: 0.16
Auto-ignition temperature: 510°C
Viscosity: 0,44 mPa/s at 20°C 
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. 

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Oxygen should be administered exclusively by specially trained first aid or medical personnel.
Do NOT take working clothes home.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
See also ICSC 88, 492, 671, 1118. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations