IPCS INCHEM Home
2,4-TOLUENE DIISOCYANATEICSC: 0339
March 1995
CAS #: 584-84-9TDI
4-Methyl-meta-phenylene diisocyanate
2,4-Diisocyanatotoluene
2,4-Diisocyanato-1-methylbenzene
UN #: 2078
EINECS #: 209-544-5

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  Risk of fire and explosion as a result of decomposition when heated.  NO open flames. NO contact with water.    Use powder, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position. 

 AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Abdominal pain. Cough. Nausea. Shortness of breath. Sore throat. Vomiting. Symptoms may be delayed. See Notes.  Use local exhaust. Use breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Burning sensation. Pain.  Protective gloves. Protective clothing.  Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain. Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in covered containers as far as possible. Treat remaining liquid with a mixture of ammonia (4-8%), detergent (2%), and water. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. If solid: sweep spilled substance into containers. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 

STORAGE
Store between 20°C and 25°C. Separated from food and feedstuffs. See Chemical Dangers. Dry. Keep in a well-ventilated room. 
PACKAGING
Do not transport with food and feedstuffs. 
2,4-TOLUENE DIISOCYANATE ICSC: 0339
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-PALE YELLOW LIQUID OR CRYSTALS WITH PUNGENT ODOUR. TURNS PALE YELLOW ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
The substance may polymerize under the influence of bases, tertiary amines and acyl chlorides. This generates fire or explosion hazard. On combustion, forms toxic gases and vapours including nitrogen oxides and isocyanates. Reacts readily with water, acids and alcohols. This generates pressure-rise explosion hazard. 

Formula: C9H6N2O2 / CH3C6H3(NCO)2
Molecular mass: 174.2
Boiling point: 251°C
Melting point: 22°C
Relative density (water = 1): 1.2
Solubility in water: reaction
Vapour pressure, Pa at 20°C: 1.3
Relative vapour density (air = 1): 6.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 127°C c.c.
Auto-ignition temperature: 620°C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 0.21  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol and by ingestion. 

Effects of short-term exposure
The substance, the vapour of this substance and the aerosol are irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause asthma-like reactions. Inhalation of the vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans. 


Occupational exposure limits
TLV: 0.001 ppm as TWA; 0.005 ppm as STEL; (skin); (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: sensitization of respiratory tract and skin (SAH); carcinogen category: 3A 

ENVIRONMENT
 

NOTES
Technical toluene diisocyanate is a mixture of 2,4- and 2,6-isomers (80:20), TDI is a common name.
Depending on the degree of exposure, periodic medical examination is suggested.
Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The odour warning when the exposure limit value is exceeded is insufficient. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T+; R: 26-36/37/38-40-42/43-52/53; S: (1/2)-23-36/37-45-61; Note: C 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.
    See Also:
       Toxicological Abbreviations