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2,4-TOLUENE DIISOCYANATEICSC: 0339
2,4TDI
4-Methyl-meta-phenylene diisocyanate
2,4-Diisocyanatotoluene
2,4-Diisocyanato-1-methylbenzene
May 2018
CAS #: 584-84-9
UN #: 2078
EC Number: 209-544-5

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  Risk of fire and explosion as a result of decomposition when heated.  NO open flames. NO contact with water.    Use powder, carbon dioxide, water in large amounts.  In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position. 

 AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS PREVENTION FIRST AID
Inhalation Sore throat. Cough. Headache. Nausea. Vomiting. Shortness of breath. Laboured breathing. Symptoms may be delayed. See Notes.  Use local exhaust. Use breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin Redness. Blisters. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain. Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer immediately for medical attention. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Special emergency response required. 

According to UN GHS Criteria

skull;toxiccancer;health haz
DANGER
Fatal if inhaled
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
May cause allergy or asthma symptoms or breathing difficulties if inhaled
May cause an allergic skin reaction
Suspected of causing cancer
Harmful to aquatic life with long lasting effects 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 

STORAGE
Separated from food and feedstuffs. Separated from : see Chemical Dangers. Store between 20°C and 25°C. Dry. Keep in a well-ventilated room. Store in an area without drain or sewer access. Refer to the manufacturer's instructions for proper storage conditions. 
PACKAGING
Do not transport with food and feedstuffs. 
2,4-TOLUENE DIISOCYANATE ICSC: 0339
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-PALE YELLOW LIQUID OR CRYSTALS WITH PUNGENT ODOUR. TURNS PALE YELLOW ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
The substance polymerizes with water and many chemicals in a hazardous way. This generates fire or explosion hazard. On combustion, forms toxic gases. This generates toxic hazard. 

Formula: C9H6N2O2 / CH3C6H3(NCO)2
Molecular mass: 174.2
Boiling point: 251°C
Melting point: 22°C
Relative density (water = 1): 1.2
Solubility in water: reaction
Vapour pressure, Pa at 20°C: 1.3
Relative vapour density (air = 1): 6.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 127°C c.c.
Auto-ignition temperature: 620°C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 3.4  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol and by ingestion. 

Effects of short-term exposure
The substance, the vapour of this substance and the aerosol are irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause asthma-like reactions. Inhalation of the vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.001 ppm as TWA; 0.005 ppm as STEL; (skin); (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: sensitization of respiratory tract and skin (SAH); carcinogen category: 3A 

ENVIRONMENT
The substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment. 

NOTES
Technical toluene diisocyanate is either 100% 2,4- or a mixture of 2,4- and 2,6-isomers, TDI is a common name. CAS number of the mixture is 26471-62-5.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The odour warning when the exposure limit value is exceeded is insufficient. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T+; R: 26-36/37/38-40-42/43-52/53; S: (1/2)-23-36/37-45-61; Note: C 

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    See Also:
       Toxicological Abbreviations