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para-TOLUIDINE
ICSC: 0343
Peer-Review Status: 27.11.2009 Validated
4-Aminotoluene
p-Methylaniline
1-Amino-4-methylbenzene 
CAS #: 106-49-0 RTECS #: XU3150000
UN #: 3451
EC #: 612-160-00-4
EINECS #: 203-403-1
    Formula: C7H9N / C6H4CH3NH2
Molecular mass: 107.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION Above 87°C explosive vapour/air mixtures may be formed.  Above 87°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Blue lips, fingernails and skin. Confusion. Dizziness. Headache. Shortness of breath. Weakness. Convulsions. Nausea. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Redness. Blue lips, fingernails and skin. Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. 
Eyes Redness. Pain.  Wear safety goggles.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Blue lips, fingernails and skin. Dizziness. Headache. Laboured breathing. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 23/24/25-36-40-43-50; S: (1/2)-28-36/37-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Combustible liquid
Toxic if swallowed
Toxic in contact with skin
Toxic if inhaled
Causes eye irritation
May cause an allergic skin reaction
Causes damage to blood
Very toxic to aquatic life 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F2; R0.  Provision to contain effluent from fire extinguishing. Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Ventilation along the floor. Keep in the dark. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS FLAKES. TURNS DARK ON EXPOSURE TO AIR AND LIGHT. 

Physical dangers
As a result of flow, agitation, etc., electrostatic charges can be generated. 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. Reacts with strong oxidants and strong acids. Attacks some forms of plastic. 

Occupational exposure limits
TLV: 2ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2009).
MAK: Carcinogen category: 3B; Skin absorption (H); Sensitization of skin (SH); (DFG 2009). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
The substance is irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Tumours have been detected in experimental animals but may not be relevant to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 200°C
Melting point: 44-45°C
Relative density (water = 1): 1.05
Solubility in water, g/100ml at 20°C: 0.75 (poor)
Vapour pressure, kPa at 42°C: 0.13
Relative vapour density (air = 1): 3.7
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 87°C c.c.
Auto-ignition temperature: 480°C
Explosive limits, vol% in air: 1.1-6.6
Octanol/water partition coefficient as log Pow: 1.39  
The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home.
See also ICSC 0341 o-Toluidine and 0342 m-Toluidine.. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations