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ARSENIC PENTOXIDE
ICSC: 0377
Peer-Review Status: 12.04.2013 Validated
Arsenic (V) oxide
Arsenic acid anhydride
Arsenic anhydride
Diarsenic pentoxide 
CAS #: 1303-28-2 RTECS #: CG2275000
UN #: 1559
EC #: 033-004-00-6
EINECS #: 215-116-9
    Formula: As2O5
Molecular mass: 229.8

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Sore throat. Headache. Dizziness. Weakness. Shortness of breath. Chest pain. See Notes. See Ingestion.  Use closed system and breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin Redness. Burning sensation. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection if powder.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Vomiting. Abdominal pain. Diarrhoea. Severe thirst. Muscle cramps. Shock or collapse. Symptoms may be delayed.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T, N; R: 45-23/25-50/53; S: 53-45-60-61; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Fatal if swallowed
Causes skin and eye irritation
Suspected of causing genetic defects
May cause cancer
May damage fertility or the unborn child
Causes damage to the bone marrow, the blood, the cardiovascular system, the nervous system, the liver and the kidneys through prolonged or repeated exposure
Toxic to aquatic life 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F0; R0.  Separated from strong bases, reducing agents and food and feedstuffs. Dry. Well closed. 

IMPORTANT DATA
Physical State; Appearance
WHITE HYGROSCOPIC POWDER. 

Physical dangers
 

Chemical dangers
Decomposes above 300°C . This produces toxic fumes (arsenic trioxide - see ICSC 0378) and oxygen. The solution in water is a weak acid. Reacts violently with bromine pentafluoride. This generates fire and explosion hazard. Reacts with reducing agents. This produces very toxic gas (arsine - see ICSC 0222). Attacks many metals in the presence of water or moisture. 

Occupational exposure limits
TLV (as As): 0.01mg/m³ as TWA; A1 (confirmed human carcinogen); BEI issued; (ACGIH 2012).
MAK: Carcinogen category: 1; Germ cell mutagen group: 3A; (DFG 2012).
EU OEL ( selected):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. 

Effects of short-term exposure
The substance and the aerosol are irritating to the eyes, respiratory tract and skin. The substance may cause effects on the blood, cardiovascular system, liver and central nervous system. The effects may be delayed. See Notes. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the skin (hyperkeratosis), cardiovascular system, bone marrow (hematopoietic changes), central nervous system, peripheral nervous system, kidneys and liver. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 315°C
Density: 4.3 g/cm³
Solubility in water, g/100ml at 20°C: 65.8 (good) 
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Do NOT take working clothes home.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of acute poisoning do not become manifest until 0.5 to several hours.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
The recommendations on this Card also apply to inorganic pentavalent arsenic compounds (arsenates). 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations