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N,N-DIMETHYLFORMAMIDEICSC: 0457
April 2014
CAS #: 68-12-2Dimethylformamide
DMF
DMFA
N-Formyldimethylamine
UN #: 2265
EINECS #: 200-679-5

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Flammable. Gives off irritating or toxic fumes (or gases) in a fire.  Above 58°C explosive vapour/air mixtures may be formed.  NO open flames, NO sparks and NO smoking. NO contact with oxidizing agents.  Above 58°C use a closed system and ventilation.  Use water spray, powder, alcohol-resistant foam, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Sore throat. Abdominal pain. Diarrhoea. Vomiting. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! See Inhalation.  Barrier cream. Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Aspiration hazard! Abdominal pain. Jaundice.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

flam;flameexcl mark;warncancer;health haz
DANGER
Flammable liquid and vapour
May be harmful if swallowed or in contact with skin
Harmful if inhaled
Causes serious eye irritation
May damage fertility or the unborn child
May cause damage to liver
May be harmful if swallowed and enters airways 

Transportation
UN Classification
UN Hazard Class: 3; UN Pack Group: III 

STORAGE
Separated from incompatible materials. See Chemical Dangers. 
PACKAGING
 
N,N-DIMETHYLFORMAMIDE ICSC: 0457
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts violently with strong oxidants, halogens, halogenated hydrocarbons and nitrates. Attacks some plastics and rubber. 

Formula: C3H7NO / HCON(CH3)2
Molecular mass: 73.1
Boiling point: 153°C
Melting point: -61°C
Relative density (water = 1): 0.95
Solubility in water: miscible
Vapour pressure, kPa at 25°C: 0.49
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 58°C c.c.
Auto-ignition temperature: 440°C
Octanol/water partition coefficient as log Pow: -0.87
Viscosity: 0.85 mm²/s at 25°C 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the liver. This may result in tissue lesions. The effects may be delayed. Medical observation is indicated. See Notes. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
The substance may have effects on the liver. This may result in impaired functions. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


Occupational exposure limits
TLV: 10 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued.
MAK: 15 mg/m3, 5 ppm; peak limitation category: II(2); skin absorption (H); carcinogen category: 4; pregnancy risk group: B.
EU-OEL: 15 mg/m3, 5 ppm as TWA; 30 mg/m3, 10 ppm as STEL; (skin) 

ENVIRONMENT
 

NOTES
The symptoms of poisoning do not become manifest until a few hours or even days have passed.
Use of alcoholic beverages enhances the harmful effect.
Environmental effects from the substance have been investigated but none has been found. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T; R: 61-20/21-36; S: 53-45; Note: E 

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    See Also:
       Toxicological Abbreviations