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ISOPHORONE DIISOCYANATE
ICSC: 0499
Peer-Review Status: 11.11.2008 Validated
3-Isocyanatomethyl - 3,5,5-trimethylcyclohexyl isocyanate
Isocyanic acid, methylene (3,5,5-trimethyl-3, 1-cyclohexylene)ester
IPDI 
CAS #: 4098-71-9 RTECS #: NQ9370000
UN #: 2290
EC #: 615-008-00-5
EINECS #: 223-861-6
    Formula: C12H18N2O2 / (CH3)2C6H7(CH3)(N=C=O)CH2N=C=O
Molecular mass: 222.3

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT!   
Inhalation Cough. Sore throat. Burning sensation.  Use closed system.  Fresh air, rest. Half-upright position. Refer immediately for medical attention. 
Skin Redness. Pain. Serious skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Sore throat. Burning sensation. Abdominal pain.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Treat remaining liquid with a mixture of ammonia (4-8%), detergent (2%), and water. Do NOT let this chemical enter the environment.  Airtight.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 23-36/37/38-42/43-51/53; S: (1/2)-26-28-38-45-61; Note: 2 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Fatal if inhaled
Harmful in contact with skin
Causes severe skin burns and eye damage
Causes serious eye irritation
May cause allergic or asthmatic symptoms or breathing difficulties if inhaled
May cause allergic skin reaction 
corrskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S2290 or 61GT1-III.
NFPA Code: H2; F1; R1; W. 
Separated from bases, acids, alcohols, amines, amides, phenols, mercaptans and food and feedstuffs. Keep in a well-ventilated room. Well closed. Cool. Dry. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH PUNGENT ODOUR. 

Physical dangers
 

Chemical dangers
The substance may polymerize. Decomposes on burning. This produces toxic and corrosive fumes including hydrogen cyanide and nitrogen oxides. Reacts with acids, alcohol, amines, bases, amides, phenols and mercaptans. This generates toxic, fire and explosion hazard. Attacks plastics and rubber. 

Occupational exposure limits
TLV: 0.005ppm as TWA; (ACGIH 2008).
MAK: 0.005 ppm; Peak limitation category: I(1); Pregnancy risk group: D; Sensitization of respiratory tract and skin (SAH); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and through the skin. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying. 

Effects of short-term exposure
The substance is corrosive to the skin. The substance is severely irritating to the eyes. The aerosol is irritating to the respiratory tract. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 1.33kPa: 158°C
Decomposes at 310°C
Melting point: -60°C
Relative density (water = 1): 1.06
Solubility in water, g/100ml: 15 (reaction)
Vapour pressure, Pa at 20°C: 0.04
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 155°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 0.7-4.5
Octanol/water partition coefficient as log Pow: 4.75 (calculated)  
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. 

NOTES
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations