IPCS INCHEM Home
ISOPHORONE DIISOCYANATEICSC: 0499
November 2008
CAS #: 4098-71-93-Isocyanatomethyl - 3,5,5-trimethylcyclohexyl isocyanate
Isocyanic acid, methylene (3,5,5-trimethyl-3, 1-cyclohexylene)ester
IPDI
UN #: 2290
EINECS #: 223-861-6

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.    NO open flames.    Use water spray, foam, powder, carbon dioxide.   

 AVOID ALL CONTACT!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Cough. Sore throat. Burning sensation.  Use closed system.  Fresh air, rest. Half-upright position. Refer immediately for medical attention. 
Skin Redness. Pain. Serious skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Sore throat. Burning sensation. Abdominal pain.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Treat remaining liquid with a mixture of ammonia (4-8%), detergent (2%), and water. Do NOT let this chemical enter the environment. 

According to UN GHS Criteria

corrskull;toxiccancer;health haz
DANGER
Fatal if inhaled
Harmful in contact with skin
Causes severe skin burns and eye damage
May cause allergic or asthmatic symptoms or breathing difficulties if inhaled
May cause allergic skin reaction 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Separated from bases, acids, alcohols, amines, amides, phenols, mercaptans and food and feedstuffs. Keep in a well-ventilated room. Well closed. Cool. Dry. Store in an area without drain or sewer access. 
PACKAGING
Airtight.
Do not transport with food and feedstuffs. 
ISOPHORONE DIISOCYANATE ICSC: 0499
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH PUNGENT ODOUR. 

Physical dangers
 

Chemical dangers
The substance may polymerize. Decomposes on burning. This produces toxic and corrosive fumes including hydrogen cyanide and nitrogen oxides. Reacts with acids, alcohol, amines, bases, amides, phenols and mercaptans. This generates toxic, fire and explosion hazard. Attacks plastics and rubber. 

Formula: C12H18N2O2 / (CH3)2C6H7(CH3)(N=C=O)CH2N=C=O
Molecular mass: 222.3
Boiling point at 1.33kPa: 158°C
Decomposes at 310°C
Melting point: -60°C
Relative density (water = 1): 1.06
Solubility in water, g/100ml: 15 (reaction)
Vapour pressure, Pa at 20°C: 0.04
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 155°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 0.7-4.5
Octanol/water partition coefficient as log Pow: 4.75 (calculated) 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and through the skin. 

Effects of short-term exposure
The substance is corrosive to the skin. The substance is severely irritating to the eyes. The aerosol is irritating to the respiratory tract. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C on spraying. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. 


Occupational exposure limits
TLV: 0.005 ppm as TWA.
MAK: 0.046 mg/m3, 0.005 ppm; peak limitation category: I(1); sensitization of respiratory tract and skin (SAH); pregnancy risk group: D 

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. 

NOTES
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T, N; R: 23-36/37/38-42/43-51/53; S: (1/2)-26-28-38-45-61; Note: 2 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.
    See Also:
       Toxicological Abbreviations