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NICOTINEICSC: 0519
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
beta-Pyridyl-alpha-N-methylpyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
September 1997
CAS #: 54-11-5
UN #: 1654
EC Number: 200-193-3

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  Above 95°C explosive vapour/air mixtures may be formed.  NO open flames.  Above 95°C use a closed system and ventilation.  Use water spray, powder, alcohol-resistant foam, carbon dioxide.   

 PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF (PREGNANT) WOMEN! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS PREVENTION FIRST AID
Inhalation Burning sensation. Nausea. Vomiting. Convulsions. Abdominal pain. Diarrhoea. Headache. Sweating. Weakness. Dizziness. Confusion.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Burning sensation. See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Pain. Redness.  Wear safety goggles, face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 

STORAGE
Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Ventilation along the floor. 
PACKAGING
Do not transport with food and feedstuffs. 
NICOTINE ICSC: 0519
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
OILY COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants. 

Formula: C10H14N2
Molecular mass: 162.2
Decomposes at 247°C
Melting point: -80°C
Relative density (water = 1): 1.01
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 0.006
Relative vapour density (air = 1): 5.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 95°C c.c.
Auto-ignition temperature: 240°C
Explosive limits, vol% in air: 0.7-4
Octanol/water partition coefficient as log Pow: 1.2  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the cardiovascular system and central nervous system. This may result in convulsions and respiratory failure. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.5 mg/m3, as TWA; (skin).
MAK: skin absorption (H).
EU-OEL: 0.5 mg/m3 as TWA; (skin) 

ENVIRONMENT
The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. 

NOTES
 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T+, N; R: 25-27-51/53; S: (1/2)-36/37-45-61 

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    See Also:
       Toxicological Abbreviations
       Nicotine (PIM 373)