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AMITROLE
ICSC: 0631
Peer-Review Status: 08-06-2011 Validated
1,2,4-Triazol-3-ylamine
3-Amino-1H-1,2,4-triazole
Aminotriazole 
CAS #: 61-82-5 RTECS #: XZ3850000
UN #: 3077
EC #: 613-011-00-6
EINECS #: 200-521-5
    Formula: C2H4N4
Molecular mass: 84.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible if powdered. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   STRICT HYGIENE!   
Inhalation   Avoid inhalation of dust and aerosol.  Fresh air, rest. 
Skin Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection if powder.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: Xn, N; R: 48/22-63-51/53; S: (2)-13-36/37-61 
UN Classification
UN Hazard Class: 9; UN Pack Group: III 
GHS Classification
Signal: Danger
Causes mild skin irritation
Suspected of damaging fertility or the unborn child
Causes damage to the thyroid through prolonged or repeated exposure
Toxic to aquatic life with long lasting effects 
cancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
  Store in an area without drain or sewer access. Separated from strong acids, strong oxidants, acid anhydrides and acid chlorides. Do NOT store or transport in containers made from iron, aluminium or copper and its alloys. Separated from food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
ODOURLESS COLOURLESS CRYSTALS. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes of nitrogen oxides. The substance is a weak base. Reacts violently with strong acids, strong oxidants, acid chlorides and acid anhydrides. This generates fire and explosion hazard. 

Occupational exposure limits
TLV: 0.2mg/m³ as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2010).
MAK (inhalable fraction): 0.2 mg/m³; Carcinogen category: 3B; Peak limitation category: II(8); Pregnancy risk group: C; (DFG 2008).
EU OEL ( selected):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol. 

Inhalation risk
A nuisance-causing concentration of airborne particles can be reached on spraying. 

Effects of short-term exposure
The substance is mildly irritating to the eyes and skin. 

Effects of long-term or repeated exposure
Tumours have been detected in experimental animals but may not be relevant to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes when heated
Melting point: 159°C
Solubility in water, g/l at 25°C: 280
Octanol/water partition coefficient as log Pow: -0.97
Relative density (water = 1): 1.14 at 20 °C
Relative vapour density (air = 1): 2.9
Vapour pressure, kPa at 20°C: (negligible) 
The substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Amitrole (EHC 158, 1994)
       Amitrole (HSG 85, 1994)
       Amitrole (WHO Pesticide Residues Series 4)
       Amitrole (Pesticide residues in food: 1977 evaluations)
       Amitrole (Pesticide residues in food: 1993 evaluations Part II Toxicology)
       Amitrole (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
       Amitrole  (IARC Summary & Evaluation, Supplement7, 1987)
       Amitrole  (IARC Summary & Evaluation, Volume 7, 1974)
       Amitrole  (IARC Summary & Evaluation, Volume 41, 1986)
       Amitrole  (IARC Summary & Evaluation, Volume 79, 2001)