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CYCLOPHOSPHAMIDE (ANHYDROUS)ICSC: 0689
April 2017
CAS #: 50-18-02-Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
2-H-1,3,2-Oxazaphosphorinane
UN #: 3464
EINECS #: 200-015-4

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, powder, foam, carbon dioxide.   

 AVOID ALL CONTACT! AVOID EXPOSURE OF BREASTFEEDING WOMEN!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation   Use closed system and ventilation.  Fresh air, rest. 
Skin   Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes   Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). 
Ingestion Diarrhoea. Dizziness. Nausea. Vomiting. Abdominal pain.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

skull;toxiccancer;health haz
DANGER
Toxic if swallowed
May cause genetic defects
May cause cancer
May damage fertility or the unborn child
May cause harm to breast-fed children
May cause damage to blood, bone marrow and lungs through prolonged or repeated exposure 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Separated from food and feedstuffs. Dry. Keep in the dark. Well closed. See Chemical Dangers. 
PACKAGING
 
CYCLOPHOSPHAMIDE (ANHYDROUS) ICSC: 0689
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
FINE WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic fumes including phosphorus oxides and nitrogen oxides. Decomposes under the influence of strong oxidants, moisture and light. 

Formula: C7H15Cl2N2O2P
Molecular mass: 261.1
Melting point: 49.5 - 53°C
Boiling point: 336°C
Density: 1.48 g/cm³
Solubility in water, g/l at 20°C: 40 (moderate)
Vapour pressure, Pa at 25°C: 0.006 (calculated)
Flash point: 113°C c.c.
Octanol/water partition coefficient as log Pow: 0.63  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion and by inhalation of its aerosol. 

Effects of short-term exposure
The substance may cause effects on the blood, bladder, central nervous system and heart. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
The substance may have effects on the blood, bladder, lungs and bone marrow. This may result in leucopenia, cystitis and pulmonary fibrosis. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells. Causes serious reproductive toxicity in humans. 


Occupational exposure limits
 

ENVIRONMENT
Environmental effects from the substance have not been investigated adequately. 

NOTES
CAS No. for monohydrate is 6055-19-2.
Depending on the degree of exposure, periodic medical examination is suggested.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
  EC Classification
 

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    See Also:
       Toxicological Abbreviations
       Cyclophosphamide  (IARC Summary & Evaluation, Supplement7, 1987)
       Cyclophosphamide (IARC Summary & Evaluation, Volume 9, 1975)
       Cyclophosphamide (IARC Summary & Evaluation, Volume 26, 1981)