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CYCLOPHOSPHAMIDE
ICSC: 0689
Peer-Review Status: 10.08.1997 Validated
2-Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
CAS #: 50-18-0 RTECS #: RP5950000
EINECS #: 200-015-4
    Formula: C7H15Cl2N2O2P
Molecular mass: 261.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! IN ALL CASES CONSULT A DOCTOR! 
Inhalation See Ingestion.  Use closed system or ventilation.  Fresh air, rest. Refer for medical attention. 
Skin Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Diarrhoea. Dizziness. Headache. Nausea. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Consult an expert! Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.   
EC Classification
 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Separated from food and feedstuffs. See Chemical Dangers. Dry. Keep in the dark. Well closed. 

IMPORTANT DATA
Physical State; Appearance
FINE WHITE ODOURLESS CRYSTALLINE POWDER (MONOHYDRATE). LIQUEFIES ON LOSS OF ITS WATER OF CRYSTALLIZATION. TURNS DARK ON EXPOSURE TO LIGHT. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic fumes including phosphorus oxides and nitrogen oxides. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood, bladder, central nervous system and heart. 

Effects of long-term or repeated exposure
The substance may have effects on the blood, bladder, lungs and bone marrow. This may result in leucopenia, cystitis and pulmonary fibrosis. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells. Causes serious reproductive toxicity in humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 41-45°C (monohydrate)
Solubility in water, g/100ml: 4  
 

NOTES
The substance is combustible but no flash point is available in literature.
Depending on the degree of exposure, periodic medical examination is suggested.
Do NOT take working clothes home.
Endoxan, Mitoxan, Genoxal, Procytox, Sendoxan, Cytophosphan are trade names. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Cyclophosphamide  (IARC Summary & Evaluation, Supplement7, 1987)
       Cyclophosphamide (IARC Summary & Evaluation, Volume 9, 1975)
       Cyclophosphamide (IARC Summary & Evaluation, Volume 26, 1981)