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1,4-DINITROBENZENE
ICSC: 0692
Peer-Review Status: 03.05.2002 Validated
1,4-Dinitrobenzol
p-Dinitrobenzene
1,4-DNB 
CAS #: 100-25-4 RTECS #: CZ7525000
UN #: 3443
EC #: 609-004-00-2
EINECS #: 202-833-7
    Formula: C6H4(NO2)2 / C6H4N2O4
Molecular mass: 168.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.  In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. 
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE!   
Inhalation Burning sensation. Blue lips, fingernails and skin. Dizziness. Headache. Laboured breathing. Nausea. Weakness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Consult an expert! Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T+, N; R: 26/27/28-33-50/53; S: (1/2)-28-36/37-45-60-61; Note: C 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S3443-S.  Separated from strong oxidants, strong bases, strong acids and food and feedstuffs. See Chemical Dangers. 

IMPORTANT DATA
Physical State; Appearance
WHITE-TO-PALE-YELLOW CRYSTALS. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
On combustion, forms toxic gases and fumes including nitrogen oxides. Reacts violently with strong oxidants, strong bases and metals (tin and zinc). This generates fire and explosion hazard. Mixtures with nitric acid are highly explosive. 

Occupational exposure limits
TLV: 0.15ppm as TWA; (skin); BEI issued; (ACGIH 2004).
MAK: Carcinogen category: 3B; Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the blood. This may result in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in anaemia. The substance may have effects on the liver. This may result in liver impairment. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 299°C
Melting point: 173-174°C
Density: 1.6 g/cm³
Solubility in water: none
Vapour pressure, kPa at 20°C: <0.1
Relative vapour density (air = 1): 5.8
Flash point: 150°C
Octanol/water partition coefficient as log Pow: 1.46/1.49  
The substance is toxic to aquatic organisms. 

NOTES
Use of alcoholic beverages enhances the harmful effect.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Dithane A-4 is a trade name.
See ICSC 0460 (1,2-Dinitrobenzene), 0691 (1,3-Dinitrobenzene), 0725 (Dinitrobenzene, mixed isomers).
NFPA Code: H3; F1; R4; for 1,2-Dinitrobenzene.
Card has been partly updated in April 2005.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations