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THIRAM
ICSC: 0757
Peer-Review Status: 04.12.2000 Validated
Tetramethylthiuram disulfide
Bis (dimethylthiocarbamoyl) disulfide
TMTD
Tetramethylthioperoxydicarbonic diamide (((H2N)C(S))2S2) 
CAS #: 137-26-8 RTECS #: JO1400000
UN #: 3077
EC #: 006-005-00-4
EINECS #: 205-286-2
    Formula: C6H12N2S4 / (CH3)2N-CS-S-S-CS-N(CH3)2
Molecular mass: 240.4

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.   
 
EXPOSURE   AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN!   
Inhalation Confusion. Cough. Dizziness. Headache. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness. Pain.  Wear safety spectacles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: Xn, N; R: 20/22-36/38-43-48/22-50/53; S: (2)-26-36/37-60-61 
UN Classification
UN Hazard Class: 9; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-90GM7-III.  Separated from acids, strong oxidants and food and feedstuffs. Dry. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
Decomposes on burning. This produces toxic fumes including sulfur oxides and carbon sulfide. Reacts with strong oxidants, acids and oxidizable materials. 

Occupational exposure limits
TLV: 1mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK (inhalable fraction): 5 mg/m³; Peak limitation category: II(1); Pregnancy risk group: D; Sensitization of skin (SH); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the thyroid and liver. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 2.6kPa: 129°C
See Notes.
Melting point: 155-156°C
See Notes.
Density: 1.3 g/cm³
Solubility in water: none
Vapour pressure at 20°C: negligible
Flash point: 89°C c.c.
See Notes.
Octanol/water partition coefficient as log Pow: 1.82  
The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. 

NOTES
Physical properties reported in literature are inconsistent.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Use of alcoholic beverages enhances the harmful effect.
If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).
Card has been partly updated in October 2004.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Thiram (FAO Meeting Report PL/1965/10/1)
       Thiram (FAO/PL:1967/M/11/1)
       Thiram (Pesticide residues in food: 1984 evaluations)
       Thiram (Pesticide residues in food: 1992 evaluations Part II Toxicology)
       Thiram (IARC Summary & Evaluation, Volume 53, 1991)