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VAMIDOTHIONICSC: 0758
October 2001
CAS #: 2275-23-2O,O-Dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl) phosphorothioate
O,O-Dimethyl S-2-(1-N-methylcarbamoylethylmercapto)ethyl thiophosphate
N-Methyl O,O-dimethylthiolophosphoryl-5-thia-3-methyl-2-valeramide
UN #: 2783
EINECS #: 218-894-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, powder, foam, carbon dioxide.   

 PREVENT DISPERSION OF DUST! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Laboured breathing. Convulsions. Unconsciousness.  Use ventilation (not if powder), local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Vomiting. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Do NOT wash away into sewer. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. 
PACKAGING
Do not transport with food and feedstuffs. 
VAMIDOTHION ICSC: 0758
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. 

Formula: C8H18NO4PS2
Molecular mass: 287.36
Melting point: 46-48°C
Solubility in water: very good
Vapour pressure: negligible at room temperature 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Effects of short-term exposure
The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Exposure at high levels could cause death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


Occupational exposure limits
 

ENVIRONMENT
The substance is harmful to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. Avoid release to the environment in circumstances different to normal use. 

NOTES
Depending on the degree of exposure, periodic medical examination is indicated.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).
Carrier solvents used in commercial formulations may change physical and toxicological properties. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T, N; R: 21-25-50; S: (1/2)-36/37-45-61 

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    See Also:
       Toxicological Abbreviations
       Vamidothion (WHO Pesticide Residues Series 3)
       Vamidothion (Pesticide residues in food: 1982 evaluations)
       Vamidothion (Pesticide residues in food: 1985 evaluations Part II Toxicology)
       Vamidothion (Pesticide residues in food: 1988 evaluations Part II Toxicology)