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WARFARIN
ICSC: 0821
Peer-Review Status: 12.11.2010 Validated
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
(RS)-4-hydroxy-3-(3-oxo-1-phenylbutyl)coumarin 
CAS #: 81-81-2 RTECS #: GN4550000
UN #: 3027
EC #: 607-056-00-0
EINECS #: 201-377-6
    Formula: C19H16O4
Molecular mass: 308.3

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames. NO contact with strong oxidizing agents.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT! PREVENT DISPERSION OF DUST!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Coughing up blood. Blood in the urine. Bleeding under the skin. Confusion. Symptoms may be delayed. See Notes.  Use closed system.  Refer for medical attention. 
Skin EASILY ABSORBED! See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. See Notes. Rinse and then wash skin with water and soap. Refer immediately for medical attention . 
Eyes   Wear face shield or eye protection in combination with breathing protection if powder.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion Diarrhoea. Nausea. Vomiting. Abdominal pain. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T; R: 61-48/25-52/53; S: 53-45-61; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 
GHS Classification
Signal: Danger
Fatal if swallowed or if inhaled
Harmful in contact with skin
May damage fertility or the unborn child
Causes damage to blood system
Causes damage to blood system through prolonged or repeated exposure
Harmful to aquatic life 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
  Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-WHITE POWDER. 

Physical dangers
 

Chemical dangers
Reacts with strong oxidants. This generates fire and explosion hazard. Decomposes on heating. This produces irritating fumes. 

Occupational exposure limits
TLV (vapour and aerosol): 0.1mg/m³ as TWA; (ACGIH 2010).
MAK: 0.02 mg/m³; Peak limitation category: II(8); Pregnancy risk group: B; Skin absorption (H); (DFG 2010). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
The substance may cause effects on the blood. This may result in bleeding. The effects may be delayed. Medical observation is indicated. See Notes. Exposure could cause death. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in bleeding. Causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes
Melting point: 161°C
Relative density (water = 1): 1.4
Solubility in water, g/100ml at 20°C: 0.0017 (very poor)
Vapour pressure, Pa at 20°C: (negligible)
Relative vapour density (air = 1): 10.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Octanol/water partition coefficient as log Pow: 2.6  
The substance is harmful to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to mammals. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Warfarin is usually available commercially as the water soluble sodium salt (CAS 129-06-6).
The physical properties above refer to the parent substance.
The symptoms of bleeding do not become manifest after one or two days.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Do NOT take working clothes home.
This CAS number is for the racemic mixture; other CAS numbers: 5543-57-7 (S-warfarin), 5543-58-8 (R-warfarin) 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Warfarin (HSG 96, 1995)
       Warfarin (PIM 563)