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CHLORPYRIFOS
ICSC: 0851
Peer-Review Status: 11.04.2014 Validated
O,O-Diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothioate
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioic acid ester
Chlorpyrifos-ethyl
CAS #: 2921-88-2 RTECS #: TF6300000
UN #: 2783
EC #: 015-084-00-4
EINECS #: 220-864-4
    Formula: C9H11Cl3NO3PS
Molecular mass: 350.6

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Liquid formulations containing organic solvents may be flammable.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION Risk of fire and explosion if formulations contain flammable/explosive solvents.    In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! FIRST AID: USE PERSONAL PROTECTION. 
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Muscle twitching. Convulsions. Dizziness. Sweating. Wheezing. Laboured breathing. Unconsciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Refer immediately for medical attention. See Notes. 
Skin MAY BE ABSORBED! See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. See Notes. 
Eyes Redness. Pain. Pupillary constriction. Blurred vision.  Wear face shield or eye protection in combination with breathing protection if powder.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Excessive salivation. Nausea. Vomiting. Abdominal cramps. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T, N; R: 25-50/53; S: (1/2)-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Toxic if swallowed, in contact with skin or if inhaled
Causes damage to nervous system
Causes damage to the nervous system through prolonged or repeated exposure
Very toxic to aquatic life with long lasting effects 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
  Store only in original container. Keep in a well-ventilated room. Separated from food and feedstuffs. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-WHITE CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes at approximately 160°C. This produces toxic and corrosive fumes including hydrogen chloride, phosgene, phosphorus oxides, nitrogen oxides and sulfur oxides. Attacks copper and brass. 

Occupational exposure limits
TLV: 0.1mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2013). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
The substance may cause effects on the nervous system by a cholinesterase inhibiting effect. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: No boiling point at normal pressure; decomposes at 160°C
Melting point: 41-42°C
Density: 1.4 g/cm³
Solubility in water, mg/l at 25°C: 1.4 (very poor)
Vapour pressure, Pa at 25°C: 0.0024
Octanol/water partition coefficient as log Pow: 4.96  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. Bioaccumulation of this chemical may occur along the food chain, for example in fish and algae. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Do NOT take working clothes home.
Do NOT use in the vicinity of a fire or a hot surface, or during welding.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Following the disappearance of symptoms from a short-term exposure, delayed effects could become manifest (after several days or weeks).
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Chlorpyrifos (WHO Pesticide Residues Series 2)
       Chlorpyrifos (WHO Pesticide Residues Series 5)
       Chlorpyrifos (Pesticide residues in food: 1977 evaluations)
       Chlorpyrifos (Pesticide residues in food: 1981 evaluations)
       Chlorpyrifos (Pesticide residues in food: 1982 evaluations)
       Chlorpyrifos (Pesticide residues in food: 1983 evaluations)
       Chlorpyrifos (JMPR Evaluations 1999 Part II Toxicological)