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ENFLURANEICSC: 0887
October 2002
CAS #: 13838-16-92-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Ethrane
Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl
EINECS #: 237-553-4

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.        In case of fire in the surroundings, use appropriate extinguishing media.   

   
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Cough. Sore throat. Drowsiness. Weakness. Unconsciousness. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Dry skin.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear safety spectacles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: self-contained breathing apparatus. 

According to UN GHS Criteria

 

Transportation
UN Classification
 

STORAGE
Keep in a well-ventilated room. 
PACKAGING
 
ENFLURANE ICSC: 0887
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen. 

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes of hydrogen chloride and hydrogen fluoride. Attacks some plastics and rubber. 

Formula: C3H2ClF5O / CHF2OCF2CHClF
Molecular mass: 184.50
Boiling point: 56.5°C
Relative density (water = 1): 1.52
Solubility in water: poor
Vapour pressure, kPa at 20°C: 23.3
Relative vapour density (air = 1): 1.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.12
Explosive limits, vol% in air: 4.25-? 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and cardiovascular system. Exposure at high levels could cause unconsciousness. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
 


Occupational exposure limits
TLV: 75 ppm as TWA; A4 (not classifiable as a human carcinogen).
MAK: 150 mg/m3, 20 ppm; peak limitation category: II(8); pregnancy risk group: C 

ENVIRONMENT
 

NOTES
Other names: Anesthetic compound no. 347, NCS-115944, Alyrane, Efrane, Ohio 347.
Other CAS numbers: (+)-enflurane CAS 22194-21-4; (-)-enflurane CAS 22194-22-5.
Check oxygen content before entering the area.
High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death. 

ADDITIONAL INFORMATION
  EC Classification
 

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    See Also:
       Toxicological Abbreviations