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ENFLURANE
ICSC: 0887
Peer-Review Status: 10.10.2002 Validated
2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Ethrane
Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl 
CAS #: 13838-16-9 RTECS #: KN6800000
EINECS #: 237-553-4
    Formula: C3H2ClF5O / CHF2OCF2CHClF
Molecular mass: 184.50

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE      
Inhalation Cough. Sore throat. Drowsiness. Weakness. Unconciousness. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Dry skin.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear safety spectacles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: self-contained breathing apparatus.   
EC Classification
 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen. 

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes of hydrogen chloride and hydrogen fluoride. Attacks some plastics and rubber. 

Occupational exposure limits
TLV: 75ppm as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2002).
MAK: 20 ppm; Peak limitation category: II(8); Pregnancy risk group: C; (DFG 2002). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and cardiovascular system. Exposure at high levels could cause unconsciousness. 

Effects of long-term or repeated exposure
 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 56.5°C
Relative density (water = 1): 1.52
Solubility in water: poor
Vapour pressure, kPa at 20°C: 23.3
Relative vapour density (air = 1): 1.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.12
Explosive limits, vol% in air: 4.25-? 
 

NOTES
Other names: Anesthetic compound no.
347, NCS-115944, Alyrane, Efrane, Ohio 347.
Other CAS numbers: (+)-enflurane CAS 22194-21-4; (-)-enflurane CAS 22194-22-5.
Check oxygen content before entering area.
High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations