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ISOPRENE
ICSC: 0904
Peer-Review Status: 04.11.1997 Validated
2-Methyl-1,3-butadiene
beta-Methylbivinyl
2-Methylbutadiene 
CAS #: 78-79-5 RTECS #: NT4037000
UN #: 1218 (inhibited)
EC #: 601-014-00-5
EINECS #: 201-143-3
    Formula: C5H8 / CH2=C(CH3)CH=CH2
Molecular mass: 68.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Extremely flammable.  NO open flames, NO sparks and NO smoking.  Use powder, AFFF, foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Burning sensation. Cough. Dizziness. Laboured breathing. Nausea. Shortness of breath. Sore throat.  Use ventilation. Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Pain.  Protective gloves.  Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Burning sensation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.   
EC Classification
Symbol: F+, T; R: 45-12-68-52/53; S: 53-45-61; Note: D 
UN Classification
UN Hazard Class: 3; UN Pack Group: I 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S1218.
NFPA Code: H2; F4; R2. 
Fireproof. Separated from combustible substances, reducing agents, strong oxidants, strong bases, strong acids, alcohols and acid chlorides. Cool. Keep in the dark. Well closed. Store only if stabilized. 

IMPORTANT DATA
Physical State; Appearance
VERY VOLATILE COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated. 

Chemical dangers
The substance can readily form explosive peroxides. The substance polymerizes due to heating and under the influence of many materials. This generates fire or explosion hazard. Reacts with strong oxidants, strong reducing agents, strong acids, strong bases, acid chlorides and alcohols. This generates fire and explosion hazard. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in respiratory depression. Exposure could cause lowering of consciousness. 

Effects of long-term or repeated exposure
Repeated or prolonged inhalation may cause effects on the lungs. This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 34°C
Melting point: -146°C
Relative density (water = 1): 0.7
Solubility in water: none
Vapour pressure, kPa at 20°C: 53.2
Relative vapour density (air = 1): 2.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.8
Flash point: -54°C c.c.
Auto-ignition temperature: 220°C
Explosive limits, vol% in air: 1.5-8.9
Octanol/water partition coefficient as log Pow: 2.30  
The substance is harmful to aquatic organisms. 

NOTES
Usually contains inhibitors to prevent polymerization.
Data are insufficiently available on the effect of this substance on human health, therefore utmost care must be taken.
An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert.
Check for peroxides prior to distillation; eliminate if found.
Vapours are uninhibited and may polymerize, blocking valves and vents.
Card has been partly updated in October 2004.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Isoprene (IARC Summary & Evaluation, Volume 71, 1999)