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ISOPROPYL ACETATE
ICSC: 0907
Peer-Review Status: 23.03.1998 Validated
Acetic acid, 1-methylethyl ester
2-Acetoxypropane
2-Propyl acetate 
CAS #: 108-21-4 RTECS #: AI4930000
UN #: 1220
EC #: 607-024-00-6
EINECS #: 203-561-1
    Formula: C5H10O2 / (CH3)2CHCOOCH3
Molecular mass: 102.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable.  NO open flames, NO sparks and NO smoking.  Use powder, AFFF, foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE      
Inhalation Cough. Drowsiness. Headache. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Dry skin. Redness.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Dizziness.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable glass containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: F, Xi; R: 11-36-66-67; S: (2)-16-26-29-33; Note: C 
UN Classification
UN Hazard Class: 3; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S1220.
NFPA Code: H1; F3; R0. 
Fireproof. Separated from oxidants. Cool. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
Reacts violently with oxidizing materials. Attacks many plastics. 

Occupational exposure limits
TLV: 100 ppm as TWA; 200 ppm as STEL; (ACGIH 2004).
MAK: 100 ppm, 420 mg/m³; Peak limitation category: I(2); Pregnancy risk group: C; (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The vapour is irritating to the eyes and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure far above the OEL could cause lowering of consciousness. 

Effects of long-term or repeated exposure
The liquid defats the skin. Cholinesterase inhibition. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 89°C
Melting point: -73°C
Relative density (water = 1): 0.88
Solubility in water, g/100ml at 27°C: 4.3 (moderate)
Vapour pressure, kPa at 17°C: 5.3
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.15
Flash point: 2°C c.c.
Auto-ignition temperature: 460°C
Explosive limits, vol% in air: 1.8-7.8
Octanol/water partition coefficient as log Pow: 1.3  
 

NOTES
Use of alcoholic beverages enhances the harmful effect.
Card has been partly updated in October 2004.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       ISOPROPYL ACETATE (JECFA Evaluation)