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3-METHYL-2-BUTANONE
ICSC: 0922
Peer-Review Status: 12.04.2013 Validated
Methyl isopropyl ketone
2-Acetyl propane 
CAS #: 563-80-4 RTECS #: EL9100000
UN #: 2397
EC #: 606-007-00-0
EINECS #: 209-264-3
    Formula: C5H10O
Molecular mass: 86.13

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Highly flammable. Heating will cause rise in pressure with risk of bursting.  NO open flames, NO sparks and NO smoking.  Use foam, powder, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE      
Inhalation Cough. Dizziness. Headache. Nausea. Drowsiness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Redness. Dry skin.  Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Vomiting. Weakness. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Consult an expert! Personal protection: self-contained breathing apparatus. Remove all ignition sources. Collect leaking liquid in covered containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.   
EC Classification
Symbol: F; R: 11; S: (2)-9-16-33 
UN Classification
UN Hazard Class: 3; UN Pack Group: II 
GHS Classification
Signal: Danger
Highly flammable liquid and vapour
May be harmful if swallowed
Causes eye irritation
May be harmful if swallowed and enters airways 
flam;flamecancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
  Fireproof. Separated from flammable substances and strong oxidants. Well closed. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. The vapour mixes well with air, explosive mixtures are easily formed. 

Chemical dangers
Decomposes on heating. This produces irritating fumes. Reacts vigorously with oxidants. 

Occupational exposure limits
TLV: 20ppm, 70mg/m³ as TWA; (ACGIH 2012).
MAK (not established):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour. 

Inhalation risk
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system. This may result in lowering of consciousness. 

Effects of long-term or repeated exposure
May cause skin dryness or cracking 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 93-95°C
Melting point: -92°C
Density: 0.8 g/cm³
Solubility in water, g/100ml at 20°C: 0.6 (poor)
Vapour pressure, kPa at 20°C: 5.5
Relative vapour density (air = 1): 3.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.10
Flash point: -1°C c.c.
Auto-ignition temperature: 475°C
Explosive limits, vol% in air: 1.2-8
Octanol/water partition coefficient as log Pow: 0.84
Viscosity: 0.63 mm²/s at 16°C 
 

NOTES
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations