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BRUCINE, ANHYDROUSICSC: 1017
June 2002
CAS #: 357-57-310,11-Dimethoxystrychnine
2,3-Dimethoxystrychnidin-10-one
2,3-Dimethylstrychnine
Dimethoxystrychnine
UN #: 1570
EINECS #: 206-614-7

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, powder, foam, carbon dioxide.   

 STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation See Ingestion.  Use ventilation (not if powder), local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Headache. Nausea. Vomiting. Muscle twitching. Restlessness. Convulsions. Laboured breathing.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . Avoid unnecessary stimulation of the victim. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 

STORAGE
Separated from strong oxidants and food and feedstuffs. Dry. Well closed. 
PACKAGING
Do not transport with food and feedstuffs. 
BRUCINE, ANHYDROUS ICSC: 1017
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS OR WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base. Reacts with strong oxidants. This generates fire and explosion hazard. 

Formula: C23H26N2O4
Molecular mass: 394.47
Boiling point: 470°C
Melting point: 178°C
Solubility in water: poor
Octanol/water partition coefficient as log Pow: 0.98  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Effects of short-term exposure
May cause mechanical irritation. The substance may cause effects on the nervous system and eyes. This may result in convulsions and respiratory paralysis. Exposure could cause death. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
 


Occupational exposure limits
 

ENVIRONMENT
The substance is harmful to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds. 

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
The recommendations on this Card also apply to Brucine hydrate (CAS 5892-11-5). 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T+; R: 26/28-52/53; S: (1/2)-13-45-61 

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    See Also:
       Toxicological Abbreviations