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PIPERAZINE (anhydrous)
ICSC: 1032
Peer-Review Status: 05.07.2003 Validated
Antiren
1,4-Diazacyclohexane
1,4-Diethylenediamine
Diethyleneimine
Hexahydropirazine 
CAS #: 110-85-0 RTECS #: TK7800000
UN #: 2579
EC #: 612-057-00-4
EINECS #: 203-808-3
    Formula: C4H10N2
Molecular mass: 86.14

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 65°C explosive vapour/air mixtures may be formed.  Above 65°C use a closed system and ventilation.   
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Burning sensation. Cough. Sore throat. Shortness of breath. Laboured breathing. Wheezing.  Avoid inhalation of dust. Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Skin burns. Pain. Blisters.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain. Severe deep burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Burning sensation. Abdominal pain. Nausea. Vomiting. Headache. Weakness. Convulsions. Shock or collapse.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.   
EC Classification
Symbol: C; R: 34-42/43-52/53; S: (1/2)-22-26-36/37/39-45-61 
UN Classification
UN Hazard Class: 8; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-80GC8-II+III.
NFPA Code: H3; F2; R1. 
Separated from strong acids, strong oxidants, acid anhydrides, metals and food and feedstuffs. Dry. Well closed. 

IMPORTANT DATA
Physical State; Appearance
HYGROSCOPIC COLOURLESS CRYSTALS OR WHITE FLAKES WITH PUNGENT ODOUR. 

Physical dangers
No data. 

Chemical dangers
Decomposes on burning. This produces toxic and corrosive gases including nitrogen oxides. The solution in water is a medium strong base. Reacts with acid anhydrides, strong acids and strong oxidants. This generates fire hazard. Attacks many metals. This produces flammable/explosive gas (hydrogen - see ICSC 0001). 

Occupational exposure limits
MAK: Sensitization of respiratory tract and skin (SAH); (DFG 2002). 

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. Ingestion of large amounts could cause effects on the nervous system. This may result in impaired functions and unconsciousness. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 146°C
Melting point: 106°C
Density: 1.1 g/cm³
Solubility in water, g/100ml at 20°C: 15
Vapour pressure, Pa at 20°C: 21
Relative vapour density (air = 1): 3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1
Flash point: 65°C
Auto-ignition temperature: 320°C
Explosive limits, vol% in air: 4-14
Octanol/water partition coefficient as log Pow: -1.17  
This substance may be hazardous to the environment. Special attention should be given to fish. 

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation is therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations