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T.E.P.P.
ICSC: 1158
Peer-Review Status: 22.04.1994 Validated
Tetraethyl pyrophosphate
Diphosphoric acid, tetraethyl ester
Tetraethyl diphosphate 
CAS #: 107-49-3 RTECS #: UX6825000
UN #: 3018
EC #: 015-025-00-2
EINECS #: 203-495-3
    Formula: C8H20O7P2 / (C2H5O)2-PO-O-PO-(OC2H5)2
Molecular mass: 290.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Risk of fire and explosion.    In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Nausea. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Laboured breathing. Dizziness. Incoordination. Convulsions. Vomiting. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Skin burns. Pain. Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes MAY BE ABSORBED! Redness. Pain. Pupillary constriction. Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Nausea. Vomiting. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T+, N; R: 27/28-50; S: (1/2)-36/37/39-38-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT6-I.  Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Dry. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS HYGROSCOPIC LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes above 150°C . This produces flammable gas (ethylene) and toxic fumes including phosphorous oxides. Attacks some forms of plastic, rubber and coatings. The substance is corrosive to most metals. 

Occupational exposure limits
TLV: 0.05mg/m³ as TWA; (skin); BEI issued; (ACGIH 2004).
MAK: 0.005 ppm, 0.06 mg/m³; Peak limitation category: II(2); Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin, by ingestion and through the eyes. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C ; on spraying much faster. 

Effects of short-term exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system. This may result in convulsions, respiratory failure and death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated. See Notes. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 170°C
Melting point: see Notes
Relative density (water = 1): 1.2
Solubility in water: good
Vapour pressure, Pa at 20°C: 2
Relative vapour density (air = 1): 10
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: see Notes
Auto-ignition temperature: see Notes
Octanol/water partition coefficient as log Pow: 2.94  
This substance may be hazardous to the environment. Special attention should be given to mammals, birds, bees and aquatic organisms. 

NOTES
Melting point: sets to glassy state below 0°C.
Auto-ignition temperature is unknown in literature.
The substance is combustible but no flash point is available in literature.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home.
Bladan, Fosnex, Gy-Tet 40, HETP, Hexaethyltetraphosphate, Killex, Kilmite, Lethalaire, Licophosphate, Nifos T, Pyfos, Pyro-Phos, Teep, Tetradusto 100, Tetron, Tetraspa and Vapotone are trade names.
Card has been partly updated in April 2005.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations