ICSC 1256 - DIAZOMETHANE

DIAZOMETHANE	ICSC: 1256 (May 2018)
Azimethylene Diazirine

CAS #: 334-88-3

EC Number: 206-382-7

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. Gas/air mixtures are explosive.	NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding).	Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. Combat fire from a sheltered position.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sore throat. Headache. Laboured breathing. Shortness of breath. Nausea. Vomiting. Symptoms may be delayed. See Notes.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Skin	Redness. Pain. Skin burns. Burning sensation. ON CONTACT WITH LIQUID: FROSTBITE.	Cold-insulating gloves.	ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention. Wear protective gloves when administering first aid.
Eyes	Burning sensation. Redness. Pain. Burns. Loss of vision. ON CONTACT WITH LIQUID: FROSTBITE.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Keep rinsing during transport for medical attention.
Ingestion		Do not eat, drink, or smoke during work.	Unlikely under occupational conditions.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus.	According to UN GHS Criteria DANGER Fatal if inhaled May cause cancer Causes severe skin burns and eye damage Transportation UN Classification
STORAGE
Solutions of diazomethane should not be stored. See Notes.
PACKAGING

DIAZOMETHANE

ICSC: 1256

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance YELLOW GAS WITH CHARACTERISTIC ODOUR. Physical dangers The gas is heavier than air and may travel along the ground; distant ignition possible. Chemical dangers May decompose explosively on shock, friction or concussion. May explode on heating at 100°C or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosion.	Formula: CH₂N₂ Molecular mass: 42.04 Boiling point: -23°C Melting point: -145°C Relative density (water = 1): 1.45 Solubility in water: reaction Relative vapour density (air = 1): 1.4 Flash point: Flammable gas Auto-ignition temperature: 100°C (explosion) Octanol/water partition coefficient as log Pow: 2.00 (estimated) Vapour pressure, kPa at 25°C: 520

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW GAS WITH CHARACTERISTIC ODOUR.

Physical dangers
The gas is heavier than air and may travel along the ground; distant ignition possible.

Chemical dangers
May decompose explosively on shock, friction or concussion. May explode on heating at 100°C or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosion.

Formula: CH₂N₂
Molecular mass: 42.04
Boiling point: -23°C
Melting point: -145°C
Relative density (water = 1): 1.45
Solubility in water: reaction
Relative vapour density (air = 1): 1.4
Flash point: Flammable gas
Auto-ignition temperature: 100°C (explosion)
Octanol/water partition coefficient as log Pow: 2.00 (estimated)
Vapour pressure, kPa at 25°C: 520

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation. Effects of short-term exposure The substance is very corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Inhalation of the vapour may cause asthma-like reactions (RADS). See Notes. The liquid may cause frostbite. Exposure above the OEL could cause death. Medical observation is indicated.	Inhalation risk A harmful concentration of this gas in the air will be reached very quickly on loss of containment. Effects of long-term or repeated exposure Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation.

Effects of short-term exposure
The substance is very corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Inhalation of the vapour may cause asthma-like reactions (RADS). See Notes. The liquid may cause frostbite. Exposure above the OEL could cause death. Medical observation is indicated.

Inhalation risk
A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Effects of long-term or repeated exposure
Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.2 ppm as TWA; A2 (suspected human carcinogen). MAK: carcinogen category: 2

ENVIRONMENT

NOTES
Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. The relation between odour and the occupational exposure limit cannot be indicated. The recommendations on this Card also apply to concentrated solutions of diazomethane.

NOTES

Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
The relation between odour and the occupational exposure limit cannot be indicated.
The recommendations on this Card also apply to concentrated solutions of diazomethane.

ADDITIONAL INFORMATION

EC Classification
Symbol: T; R: 45; S: 53-45

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    See Also:
       Toxicological Abbreviations
       Diazomethane (IARC Summary & Evaluation, Volume 7, 1974)