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ISONIAZIDICSC: 1258
Isonicotinic hydrazide
4-Pyridinecarboxylic acid, hydrazide
March 1995
CAS #: 54-85-3
EC Number: 200-214-6

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.    NO open flames.    Use water spray, powder, foam, carbon dioxide.   

 PREVENT DISPERSION OF DUST!  
  SYMPTOMS PREVENTION FIRST AID
Inhalation   Use local exhaust or breathing protection.  Fresh air, rest. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes   Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Confusion. Convulsions. Nausea. Weakness. Incoordination. Hallucinations.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: P2 filter respirator for harmful particles. 

According to UN GHS Criteria

 

Transportation
UN Classification
 

STORAGE
Cool. Well closed. 
PACKAGING
 
ISONIAZID ICSC: 1258
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. 

Formula: C6H7N3O
Molecular mass: 137.1
Melting point: 170-173°C
Solubility in water, g/100ml at 20°C: 12.5  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion. 

Effects of short-term exposure
The substance may cause effects on the nervous system and kidneys. This may result in disorientation, lethargy, coma and metabolic acidosis. Exposure at high levels could cause death. Exposure could cause unconsciousness. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
The substance may have effects on the central nervous system and liver. This may result in tissue lesions and impaired functions. 


OCCUPATIONAL EXPOSURE LIMITS
 

ENVIRONMENT
 

NOTES
Many trade names are known for this compound. 

ADDITIONAL INFORMATION
  EC Classification
 

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    See Also:
       Toxicological Abbreviations
       Isoniazid (PIM 288)