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DISULFIRAM
ICSC: 1438
Peer-Review Status: 10.09.2002 Validated
Tetraethylthiuramdisulfide
1,1'-Dithiobis(N,N-diethylthioformamide)
bis-(N,N-Diethylthiocarbamoyl)disulfide
TETD 
CAS #: 97-77-8 RTECS #: JO1225000
EC #: 006-079-00-8
EINECS #: 202-607-8
    Formula: C10H20N2S4 / ((C2H5)2NCS)2S2
Molecular mass: 269.6

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust. Prevent build-up of electrostatic charges (e.g., by grounding).   
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN!   
Inhalation   Use ventilation, local exhaust or breathing protection.   
Skin   Protective gloves.  Rinse skin with plenty of water or shower. 
Eyes   Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Confusion. Headache. Nausea. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.   
EC Classification
Symbol: Xn, N; R: 22-43-48/22-50/53; S: (2)-24-37-60-61 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Separated from strong oxidants. 

IMPORTANT DATA
Physical State; Appearance
WHITE-TO-GREY POWDER WITH CHARACTERISTIC ODOUR. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. 

Chemical dangers
Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides and sulfur oxides. Reacts violently with strong oxidants. Attacks copper. 

Occupational exposure limits
TLV: 2mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK (inhalable fraction): 2 mg/m³; Peak limitation category: II(8); Pregnancy risk group: D; Sensitization of skin (SH); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of dust and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the endocrine system, liver, nervous system and thyroid. This may result in impaired functions. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 2.3kPa: 117°C
Melting point: 71°C
Density: 1.3 g/cm³
Solubility in water, g/100ml: 0.02
Octanol/water partition coefficient as log Pow: 3.9  
The substance is toxic to aquatic organisms. 

NOTES
In combination with alcohol the substance causes effects on cardiovascular and central nervous systems resulting in palpitation, hypotension and hyperventilation.
The effects may be delayed.
Do NOT take working clothes home.
Antabuse and Rosulfiram are trade names.
Card has been partly updated in April 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Disulfiram (IARC Summary & Evaluation, Volume 12, 1976)