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n-BUTYL ISOCYANATE
ICSC: 1642
Peer-Review Status: 19.04.2007 Validated
1-Isocyanatobutane 
CAS #: 111-36-4 RTECS #: NQ8250000
UN #: 2485
EINECS #: 203-862-8
    Formula: C5H9NO / CH3(CH2)3NCO
Molecular mass: 99.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable. Heating will cause rise in pressure with risk of bursting.  NO open flames, NO sparks and NO smoking.  Use dry powder, foam, carbon dioxide. NO water. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting.  In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Sore throat. Laboured breathing. Burning sensation.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin Redness. Pain. Skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain. Burns.  Wear safety goggles or eye protection in combination with breathing protection.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Blue haze and halo. 
Ingestion Abdominal pain. Burning sensation. Shock or collapse.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Ventilation. Remove all ignition sources. Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT let this chemical enter the environment.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
UN Hazard Class: 6.1; UN Subsidiary Risks: 3; UN Pack Group: I 
GHS Classification
Signal: Danger
Highly flammable liquid and vapour
Fatal if inhaled vapour
Harmful if swallowed
Catches fire spontaneously if exposed to air
May cause allergic skin reaction
Causes damage to lungs if if inhaled 
flam;flamecorrskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S2485 or 61GTF1-I.
NFPA Code: H3; F3; R2; W. 
Fireproof. Separated from strong oxidants and food and feedstuffs. Cool. See Chemical Dangers. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID. 

Physical dangers
The vapour mixes well with air, explosive mixtures are easily formed. 

Chemical dangers
The substance may polymerize due to heating. Decomposes on burning. This produces toxic gases including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants and water. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
Serious by all routes of exposure. 

Inhalation risk
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 115°C
Melting point: <-70°C
Density: 0.9 g/cm³
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 2.1
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 11°C c.c.
Auto-ignition temperature: 425°C
Explosive limits, vol% in air: 1.3-10 
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. 

NOTES
Some isocyanates are well known to cause respiratory sensitization.
However, there are no reports of n-butyl isocyanate or other monoisocyanates causing respiratory sensitization.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation is therefore essential. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations