IPCS INCHEM Home
n-BUTYL ISOCYANATEICSC: 1642
1-IsocyanatobutaneApril 2007
CAS #: 111-36-4
UN #: 2485
EC Number: 203-862-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Highly flammable. Heating will cause rise in pressure with risk of bursting.  Vapour/air mixtures are explosive.  NO open flames, NO sparks and NO smoking.  Closed system, ventilation, explosion-proof electrical equipment and lighting.  Use dry powder, foam, carbon dioxide. NO water.  In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position. 

 AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Laboured breathing. Burning sensation.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin Redness. Pain. Skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain. Burns.  Wear safety goggles or eye protection in combination with breathing protection.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). 
Ingestion Abdominal pain. Burning sensation. Shock or collapse.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Evacuate danger area! Ventilation. Remove all ignition sources. Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. 

According to UN GHS Criteria

flam;flamecorrskull;toxiccancer;health haz
DANGER
Highly flammable liquid and vapour
Fatal if inhaled
Harmful if swallowed
Causes severe skin burns and eye damage
May cause allergic skin reaction
Causes damage to lungs if inhaled 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Subsidiary Risks: 3; UN Pack Group: I 

STORAGE
Fireproof. Separated from strong oxidants and food and feedstuffs. Cool. See Chemical Dangers. Store in an area without drain or sewer access. 
PACKAGING
Do not transport with food and feedstuffs. 
n-BUTYL ISOCYANATE ICSC: 1642
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID. 

Physical dangers
The vapour mixes well with air, explosive mixtures are easily formed. 

Chemical dangers
The substance may polymerize due to heating. Decomposes on burning. This produces toxic gases including nitrogen oxides and hydrogen cyanide. Reacts violently with strong oxidants and water. 

Formula: C5H9NO / CH3(CH2)3NCO
Molecular mass: 99.1
Boiling point: 115°C
Melting point: <-70°C
Density: 0.9 g/cm³
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 2.1
Relative vapour density (air = 1): 3.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.05
Flash point: 11°C c.c.
Auto-ignition temperature: 425°C
Explosive limits, vol% in air: 1.3-10 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
Serious local effects by all routes of exposure. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. 

Inhalation risk
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. See Notes. 


OCCUPATIONAL EXPOSURE LIMITS
 

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. 

NOTES
Some isocyanates are well known to cause respiratory sensitization.
However, there are no reports of n-butyl isocyanate or other monoisocyanates causing respiratory sensitization.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. 

ADDITIONAL INFORMATION
  EC Classification
 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.
    See Also:
       Toxicological Abbreviations