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ISOBUTYL NITRITE
ICSC: 1651
Peer-Review Status: 04.05.2006 Validated
Nitrous acid, 2-methylpropyl ester
Nitrous acid, isobutyl ester 
CAS #: 542-56-3 RTECS #: RA0805000
UN #: 1992
EC #: 007-017-00-2
EINECS #: 208-819-7
    Formula: C4H9NO2 / (CH3)2CHCH2NO2
Molecular mass: 103.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking.  Use dry powder, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT!   
Inhalation Sore throat. Headache. Dizziness. Blue lips, fingernails and skin. Nausea. Confusion. Convulsions. Unconciousness. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin   Protective gloves. Protective clothing.  Rinse and then wash skin with water and soap. 
Eyes   Wear safety spectacles.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: self-contained breathing apparatus. Evacuate danger area! Consult an expert! Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: F, T; R: 11-20/22-45-68; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 3; UN Subsidiary Risks: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Highly flammable liquid and vapour
Harmful if swallowed
Toxic if inhaled (vapour)
Suspected of causing cancer
Causes damage to blood 
flam;flameskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30GTF1-III.  Fireproof. Separated from acids. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
Decomposes on burning. This produces toxic gases including nitrogen oxides. 

Occupational exposure limits
TLV: 1ppm (ceiling value); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2006). 

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance may cause effects on the blood and cardiovascular system. This may result in cardiac disorders and formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. Exposure at high levels could cause death. See Notes. 

Effects of long-term or repeated exposure
This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 67°C
Relative density (water = 1): 0.87
Solubility in water: very poor
Vapour pressure, kPa at 20°C: 1.3
Relative vapour density (air = 1): 3.56
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.19
Flash point: -21°C
Explosive limits, vol% in air: 1.2-26.9 
 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations