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ETHYLBIS(2-CHLOROETHYL)AMINE
ICSC: 1655
Peer-Review Status: 10.04.2008 Validated
Bis(2-chloroethyl)ethylamine
2-Chloro-N-(2-chloroethyl)-N-ethylethanamine
2-Chloro-N-(2-chloroethyl)-N-ethyl-ethanamine
2,2'-Dichloro-triethylamine
HN1
Nitrogen Mustard 
CAS #: 538-07-8 RTECS #: YE1225000
UN #: 2810
    Formula: C6H13Cl2N / (ClCH2CH2)2NC2H5
Molecular mass: 170.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, alcohol-resistant foam, carbon dioxide, powder. 
EXPLOSION     In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Sore throat. Burning sensation. Cough. Tremor. Incoordination. Convulsions. Laboured breathing. Shortness of breath. Wheezing. Symptoms may be delayed. See Notes.  Use closed system.  Half-upright position. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain. Blisters. Symptoms may be delayed. Further see Inhalation.  Protective gloves. Protective clothing.  Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. 
Eyes VAPOUR WILL BE ABSORBED! Watering of the eyes. Redness. Pain. Spasms, photophobia and dilated pupils. Blurred vision. Severe deep burns. Loss of vision.  Wear safety goggles. Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Sore throat. Abdominal pain. Burning sensation in the throat and chest. Nausea. Vomiting. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable air tight containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. NEVER direct water jet on liquid.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 
GHS Classification
Signal: Danger
Fatal if inhaled
Fatal in contact with skin
Causes skin irritation
Causes serious eye damage
May cause genetic defects
May cause cancer
Causes damage to nervous system and bone marrow
May cause respiratory irritation
Causes damage to the nervous system and the bone marrow through prolonged or repeated exposure 
skull;toxiccorrcancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H4; F2; R0.  Keep in the dark. Separated from food and feedstuffs and metals. Keep in a well-ventilated room. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
The substance polymerizes under the influence of heat and light. Attacks many metals. This produces flammable gas (hydrogen - see ICSC 0001). 

Occupational exposure limits
TLV not established.
MAK (not established):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol, through the skin and by ingestion. Serious local effects and systemic effects by all routes of exposure. 

Inhalation risk
A harmful contamination of the air will be reached quickly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
Blistering agent. Lachrymation. The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and bone marrow. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the bone marrow and central nervous system. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 194°C
Melting point: -34°C
Relative density (water = 1): 1.09
Solubility in water at 25°C: very poor
Vapour pressure, kPa at 25°C: 0.03
Relative vapour density (air = 1): 5.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 
 

NOTES
Do NOT take working clothes home.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Because many of the effects resemble those of ionizing radiation, the term "radiomimetic" is frequently used. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations