ICSC 1664 - 3-CHLORO-1,2-PROPANEDIOL (RACEMIC MIXTURE)

3-CHLORO-1,2-PROPANEDIOL (RACEMIC MIXTURE)	ICSC: 1664 (April 2009)
alpha-Chlorohydrin Glycerol alpha-monochlorohydrin Chlorhydrin 3-Chloro-1,2-dihydroxypropane

CAS #: 96-24-2

UN #: 2689

EC Number: 202-492-4

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Risk of explosion on contact with strong oxidants.	NO open flames.	Use alcohol-resistant foam, dry powder, carbon dioxide.

PREVENT GENERATION OF MISTS!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat. Further see Ingestion.	Avoid inhalation of mist.	Fresh air, rest. Refer for medical attention.
Skin	See Ingestion.	Protective gloves.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes	Redness. Pain.	Wear safety goggles.	Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
Ingestion	Cough. Sore throat. Headache. Dizziness. Drowsiness.	Do not eat, drink, or smoke during work.	Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Fatal if inhaled Toxic if swallowed Harmful in contact with skin Causes serious eye irritation Suspected of causing cancer Suspected of damaging fertility or the unborn child Causes damage to central nervous system if swallowed May cause respiratory irritation Causes damage to the kidneys through prolonged or repeated exposure if swallowed Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Dry. Well closed. Separated from strong oxidants and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

3-CHLORO-1,2-PROPANEDIOL (RACEMIC MIXTURE)

ICSC: 1664

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-PALE-YELLOW HYGROSCOPIC LIQUID. Physical dangers No data. Chemical dangers Decomposes on heating and on burning. This produces toxic fumes including hydrogen chloride (see ICSC 0163). Reacts with strong oxidants. This generates fire and explosion hazard.	Formula: C₃H₇ClO₂ / HOCH₂CHOHCH₂Cl Molecular mass: 110.5 Decomposes at 213°C Boiling point at 1.9kPa: 114-120°C Melting point: -40°C Relative density (water = 1): 1.32 Solubility in water: miscible Vapour pressure, Pa at 20°C: 27 Relative vapour density (air = 1): 3.8 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Flash point: 113°C c.c. Octanol/water partition coefficient as log Pow: -0.53 (estimated) Viscosity: 182 mm²/s at 20°C

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-PALE-YELLOW HYGROSCOPIC LIQUID.

Physical dangers
No data.

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including hydrogen chloride (see ICSC 0163). Reacts with strong oxidants. This generates fire and explosion hazard.

Formula: C₃H₇ClO₂ / HOCH₂CHOHCH₂Cl
Molecular mass: 110.5
Decomposes at 213°C
Boiling point at 1.9kPa: 114-120°C
Melting point: -40°C
Relative density (water = 1): 1.32
Solubility in water: miscible
Vapour pressure, Pa at 20°C: 27
Relative vapour density (air = 1): 3.8
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 113°C c.c.
Octanol/water partition coefficient as log Pow: -0.53 (estimated)
Viscosity: 182 mm²/s at 20°C

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system.	Inhalation risk A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. Effects of long-term or repeated exposure The substance may have effects on the kidneys. This may result in kidney impairment. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system.

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

Effects of long-term or repeated exposure
The substance may have effects on the kidneys. This may result in kidney impairment. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

OCCUPATIONAL EXPOSURE LIMITS
MAK: 0.023 mg/m³, 0.005 ppm; peak limitation category: II(8); skin absorption (H); carcinogen category: 3; pregnancy risk group: D

ENVIRONMENT

NOTES
Health effects of exposure to the substance have not been investigated adequately. CAS numbers for optical isomers are 57090-45-6 for the R(-) isomer and 60827-45-4 for the S(+) isomer.

ADDITIONAL INFORMATION

EC Classification

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    See Also:
       Toxicological Abbreviations