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KETOCONAZOLEICSC: 1700
April 2009
CAS #: 65277-42-1Ketoconazol
UN #: 2811
EINECS #: 265-667-4

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Not combustible.        In case of fire in the surroundings, use appropriate extinguishing media.   

 STRICT HYGIENE!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Cough.  Use local exhaust or breathing protection.  Fresh air, rest. 
Skin Redness.  Protective gloves.  Rinse and then wash skin with water and soap. 
Eyes   Wear safety goggles.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion Nausea. Headache. Dizziness. Vomiting. Diarrhoea.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

skull;toxiccancer;health hazenviro;aqua
DANGER
Toxic if swallowed
May damage fertility or the unborn child
Causes damage to endocrine system through prolonged or repeated exposure if swallowed
Very toxic to aquatic life 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Provision to contain effluent from fire extinguishing. Well closed. Separated from food and feedstuffs. Store in an area without drain or sewer access. 
PACKAGING
Do not transport with food and feedstuffs. 
KETOCONAZOLE ICSC: 1700
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS OR POWDER. 

Physical dangers
No data. 

Chemical dangers
No data. 

Formula: C26H28Cl2N4O4
Molecular mass: 531.5
Melting point: 148-152°C
Solubility in water: none
Vapour pressure, Pa at 25°C: (negligible)
Octanol/water partition coefficient as log Pow: 4.35  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion. 

Effects of short-term exposure
 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
The substance may have effects on the endocrine system and liver. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


Occupational exposure limits
 

ENVIRONMENT
The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Synonyms for this substance are: (+)-cis-1-Acetyl-4-4-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazine and 1-4-4-(2SR,4RS)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazin-1-ylethanone. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T, N; R: 60-25-48/22-50/53; S: 53-45-60-61; Note: E 

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    See Also:
       Toxicological Abbreviations