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DIMETHYL FUMARATEICSC: 1732
2-Butenedioic acid, dimethylester
Boletic acid dimethyl ester
Dimethyl (E)-butenedionate
trans-1,2-Ethylenedicarboxylic acid dimethyl ester
June 2012
CAS #: 624-49-7

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible.  Finely dispersed particles form explosive mixtures in air.  NO open flames.  Prevent build-up of electrostatic charges (e.g., by grounding).  Use water spray, foam, powder, alcohol-resistant foam.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT DISPERSION OF DUST!  
  SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat.  Avoid inhalation of dust.  Fresh air, rest. Seek medical attention if you feel unwell. 
Skin Redness.  Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention if skin irritation occurs. 
Eyes Redness. Pain.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Flushing of the face. Nausea. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. If appropriate, moisten first to prevent dusting. Sweep spilled substance into sealable containers. Then store and dispose of according to local regulations. Wash away remainder with plenty of water. 

According to UN GHS Criteria

excl mark;warn
WARNING
Causes serious eye irritation
Harmful in contact with skin
May be harmful if swallowed
May cause an allergic skin reaction 

Transportation
UN Classification
 

STORAGE
Keep in a well-ventilated room. Well closed. Keep in the dark. Separated from strong oxidants. 
PACKAGING
Do not transport with food and feedstuffs. 
DIMETHYL FUMARATE ICSC: 1732
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc. 

Chemical dangers
Reacts with strong oxidants. This generates fire and explosion hazard. The substance can form explosive peroxides on prolonged contact with air and light. 

Formula: C6H8O4
Molecular mass: 144.13
Boiling point: 193°C
Density: 1.37 g/cm³
Melting point: 104°C
Vapour pressure: negligible
Relative density (water = 1): 1.4
Relative vapour density (air = 1): 5
Solubility in water, g/l: 1.6 (poor)
Octanol/water partition coefficient as log Pow: 0.74 (estimated) 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by ingestion and through the skin. 

Effects of short-term exposure
The substance is irritating to the skin and respiratory tract. The substance is severely irritating to the eyes. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. 


OCCUPATIONAL EXPOSURE LIMITS
 

ENVIRONMENT
 

NOTES
Products containing more than 0.1% Dimethylfumarate are banned from the market in EU countries. 

ADDITIONAL INFORMATION
  EC Classification
 

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    See Also:
       Toxicological Abbreviations