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HYDROXYPROPYL ACRYLATE, ISOMERS
ICSC: 1742
Peer-Review Status: 31.03.2009 Validated
Propylene glycol monoacrylate
Acrylic acid, monoester with propane-1,2-diol
2-Propenoic acid, monoester with propane-1,2-diol 
CAS #: 25584-83-2 RTECS #: UD3610000
UN #: 2810
EC #: 607-108-00-2
EINECS #: 247-118-0
    Formula: C6H10O3
Molecular mass: 130.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, dry powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 97°C explosive vapour/air mixtures may be formed.  Above 97°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT! PREVENT GENERATION OF MISTS!   
Inhalation Cough. Sore throat. Burning sensation.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Abdominal pain. Burning sensation in the throat and chest. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 23/24/25-34-43; S: (1/2)-26-36/37/39-45; Note: C, D 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Harmful if swallowed
Toxic in contact with skin
Causes skin irritation
Causes serious eye irritation
May cause an allergic skin reaction
May cause respiratory irritation
May be harmful if swallowed and enters airways
Toxic to aquatic life 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F1; R2.  Separated from food and feedstuffs, strong bases and strong acids. Store only if stabilized. See Notes. Cool. Keep in the dark. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID. 

Physical dangers
No data. 

Chemical dangers
The substance may polymerize due to heating and under the influence of light, and peroxides. Decomposes on heating. This produces toxic and corrosive fumes including acrolein. Reacts violently with strong acids, strong bases, strong oxidants and peroxides. This generates fire hazard. 

Occupational exposure limits
TLV not established.
MAK (2b (not established but data is available)): Sensitization of skin (SH); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is severely irritating to the skin and eyes. The substance is irritating to the respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 205.7°C
Melting point: -23.4°C
Density: 1.05 g/cm³
Solubility in water, g/100ml at 25°C: 30.7 (good)
Vapour pressure, Pa at 25°C: 4
Relative vapour density (air = 1): 4.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 97°C c.c.
Explosive limits, vol% in air: 1.8-?
Octanol/water partition coefficient as log Pow: 0.35
Viscosity: 8.2 mm²/s at 20°C 
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Do NOT take working clothes home.
Skin cross-sensitization with other acrylates is possible.
A typical commercial sample of hydroxypropyl acrylate contains approximately 75-80% 2-hydroxypropyl acrylate and 20-25% 1-methyl-2- hydroxyethyl acrylate. The purity of the saleable product is at least 97% combined isomers.
See also ICSC 0899.
An added stabilizer or inhibitor can influence the toxicological properties of this substance; consult an expert.
The effectiveness of phenolic inhibitors is dependent on the presence of oxygen. Store under air rather than inert atmosphere. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations