FAO Nutrition Meetings
    Report Series No. 40A,B,C
    WHO/Food Add./67.29




    TOXICOLOGICAL EVALUATION OF SOME
    ANTIMICROBIALS, ANTIOXIDANTS, EMULSIFIERS,
    STABILIZERS, FLOUR-TREATMENT AGENTS, ACIDS AND BASES





    The content of this document is the result of the deliberations of the
    Joint FAO/WHO Expert Committee on Food Additives which met at Rome,
    13-20 December, 19651 Geneva, 11-18 October, 19662




                   

    1 Ninth Report of the Joint FAO/WHO Expert Committee on Food
    Additives, FAO Nutrition Meetings Report Series, 1966 No. 40; 
    Wld Hlth Org. techn. Rep. Ser., 1966, 339

    2 Tenth Report of the Joint FAO/WHO Expert Committee on Food
    Additives, FAO Nutrition Meetings Report Series, 1967, in press; 


    Food and Agriculture Organization of the United Nations
    World Health Organization
    1967


    ISOPROPYL CITRATE MIXTURE

    Definition                    A mixture consisting of approximately
                                  27 per cent. monoisopropyl citrate
                                  9 per cent. diisopropyl citrate
                                  2 per cent. triisopropyl citrate
                                  62 per cent. mono-and diglycerides

    Description                   More readily soluble in oils than citric
                                  acid.

    Use                           As a sequestering agent in antioxidant
                                  mixtures and in fatty foods.

    Monoisopropyl Citrate

    Chemical name                 Citric acid ester of 2-Propanol

    Structural formula

                                       CH2 - COOR
                                       '
                                  HO - C - COOR
                                       '
                                       CH2 - COOR

                                  Where in the major component one R is
                                  isopropyl and the remainder are
                                  hydrogen.

    Definition                    Monoisopropyl citrate is formed by
                                  esterifying citric acid with 2-propanol
                                  resulting in a mixture of mainly
                                  monoisopropyl citrates with some di-and
                                  triisopropyl citrate. The product is the
                                  isopropyl citrate used to prepare the
                                  mixture described above.

    Description                   Monoisopropyl citrate is a viscous,
                                  colourless syrup exhibiting some
                                  crystallization upon standing.

         Specifications for monoisopropyl citrate will appear as working
    papers for the Fourth meeting of the Codex Committee on Food
    Additives, September 1967, and will be available on request from the
    Joint FAO/WHO Food Standards Branch (Codex Alimentarius) FAO, Rome.

    Biological Data

         For biological data on the isopropyl citrate mixture see the
    Sixth Report of the joint FAO/WHO Committee on Food Additives.

    Evaluation

    Level causing no toxicological effect

         Rat.  28 000 ppm in the diet, equivalent to 1400 mg/kg
    body-weight/day.

    Estimate of acceptable daily intake for man

                                  mg/kg body-weight

       Unconditional acceptance          0-7
       Conditional acceptance            7-20
    

    See Also:
       Toxicological Abbreviations
       ISOPROPYL CITRATE MIXTURE (JECFA Evaluation)