WORLD HEALTH ORGANIZATION
WHO Food Additives Series 1972, No. 1
TOXICOLOGICAL EVALUATION OF SOME
ENZYMES, MODIFIED STARCHES AND
CERTAIN OTHER SUBSTANCES
The evaluations contained in this publication were prepared by the
Joint FAO/WHO Expert Committee on Food Additives which met in Rome,
16-24 June 19711
World Health Organization
1 Fifteenth Report of the Joint FAO/WHO Expert Committee on Food
Additives, Wld Hlth Org. techn. Rep. Ser., 1972, No. 488; FAO
Nutrition Meetings Report Series, 1972, No. 50.
The monographs contained in the present volume are also issued by the
Food and Agriculture Organization of the United Nations, Rome, as FAO
Nutrition Meetings Report Series, No. 50A
(c) FAO and WHO 1972
MICROBIAL GLUCOSE OXIDASE
This enzyme preparation is prepared from some varieties of
Groups of 5 ducklings received in their diet either 0, 1, 5 or 10 per
cent. of enzyme for 29 days. Growth, feed efficiency, behaviour and
survival were similar in all groups except the 10 per cent. level
which showed some growth retardation. No gross liver lesions or
differences in mean liver weight were noted. Histopathology was
normal. No toxic element was noted (F.D.R.L., 1963).
Aspergillus niger is a contaminant of food. The available
information appears to indicate that it is not pathogenic to man. A
duckling study is available and may serve to exclude the possibility
of aflatoxin or related mycotoxin production occurring in this strain.
Temporarily not limited.*
Further work required by 1972
Adequate 90-day study in the rat.
F.D.R.L. (1963) Unpublished report No. 846OOd of the Food and Drug
Research Laboratories submitted by Miles Chem. Co.
*Except for good manufacturing practice.