IPCS INCHEM Home


    INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

    WORLD HEALTH ORGANIZATION



    TOXICOLOGICAL EVALUATION OF CERTAIN FOOD ADDITIVES



    WHO FOOD ADDITIVES SERIES 15





    Prepared by:
    The Joint FAO/WHO Expert
    Committee on Food Additives (JECFA)*

    Roma, 24 March - 2 April 1980

    World Health Organization, Geneva 1980



              

    *    Twenty-fourth Report of the Joint FAO/WHO Expert Committee on
         Food Additives, Roma, WHO Technical Report Series No. 653, 1980

         The International Programme on Chemical Safety (IPCS),
    established in 1980, is a joint venture of the United Nations
    Environment Programme (UNEP), the International Labour Organisation
    (ILO), and the World Health Organization (WHO). The overall objectives
    of the IPCS are to establish the scientific basis for assessment of
    the risk to human health and the environment from exposure to
    chemicals, through international peer-review processes, as a
    prerequisite for the assistance in strengthening national capacities
    for the sound management of chemicals.

         The Inter-Organization Programme for the Sound Management of
    Chemicals (IOMC) was established in 1995 by UNEP, ILO, the Food and
    Agriculture Organization of the United Nations, WHO, the United
    Nations Industrial Development Organization and the Organisation for
    Economic Co-operation and Development (Participating Organizations),
    following recommendations made by the 1992 UN Conference on
    Environment and Development to strengthen cooperation and increase
    coordination of the policies and activities pursued by the
    Participating Organizations, jointly or separately, to achieve the
    sound management of chemicals in relation to human health and the
    environment.

    WHO Food Additives Series, 1980, No. 15

    TOXICOLOGICAL EVALUATION OF CERTAIN FOOD ADDITIVES

    The evaluations contained in this document
    were prepared by the Joint FAO/WHO,
    Expert Committee on Food Additives*

    Rome, 24 March - 2 April 1980

              

    *    Twenty-fourth report of the Joint FAO/WHO Expert Committee on Food
         Additives, Rome, Wld Hlth Org. techn. Rep. Ser., 1980, No. 653.

    CONTENTS

    INTRODUCTION

    THE MONOGRAPHS

         Allura red AC
         Aspartame
         Butylated hydroxyanisole (BHA)
         Butylated hydroxytoluene (BHT)
         Carob bean gum
         Ethyl lactate
         Polyvinylpyrrolidone (PVP)
         Sucrose esters of fatty acids and sucroglycerides
    


    INTRODUCTION

         The monographs contained in this document have been prepared by
    the Joint FAO/WHO Expert Committee on Food Additives which was held in
    Rome from 24 March - 2 April 1980.

         Any new information and comments on the biological and
    toxicological data should be addressed to: International Programme on
    Chemical Safety (Food), Division of Environmental Health, World Health
    Organization, Avenue Appia, 1211 Geneva 27, Switzerland.

    JOINT FAO//WHO EXPERT COMMITTEE ON FOOD ADDITIVES

    Rome, 24 March - 2 April 1980

    Members invited by FAO

    Mr D. F. Dodgen, Director, Food Chemicals Codex, National Academy of
         Sciences, Washington, D.C., United States of America

    Mr A. W. Hubbard, Head, Food Science Division, Ministry of
         Agriculture, Fisheries, and Food, London, England (Chairman)

    Dr W. Kroenert, Head, Food Chemistry Division, Federal Office of
         Public Health, Berlin (West)

    Professor K. Kojima, College of Environmental Health, Azabu
         University, Sagamihara, Japan

    Professor F. Pellerin, Emile Roux Hospital Centre, Eaubonne, France

    Dr C. A. Vodoz, Firmenich & Co., Geneva, Switzerland

    Members invited by WHO*

    Dr I. C. Munro, Director, Bureau of Chemical Safety, Health Protection
         Branch, Department of National Health and Welfare, Ottawa, Canada
         (Rapporteur)

    Dr G. Nazario, Director, Food Standards, National Health Council,
         Ministry of Health, Rio de Janeiro, Brazil

    Dr E. Poulsen, Director, Institute of Toxicology, National Food
         Institute, Soborg, Denmark

    Professor M. J. Rand, Department of Pharmacology, University of
         Melbourne, Australia (Vice-Chairman)

    Professor R. Truhaut, Director, Toxicological Research Centre,
         René Descartes University, Paris, France

    Observer invited by FAO

    Mr A. Feberwee, Chairman, Codex Committee on Food Additives,
         c/o Ministry of Agriculture and Fisheries, The Hague, Netherlands

              

    *    Unable to attend: Dr M. F. Nesterin, Institute of Nutrition, Academy
         of Medical Sciences of the USSR, Moscow, USSR.

    Secretariat

    Dr H. Blumenthal, Director, Division of Toxicology, Bureau of Foods,
         Food and Drug Administration, Washington, D.C., United States of
         America (WHO Temporary Adviser)

    Dr W. H. B. Denner, Food Science Division, Ministry of Agriculture,
         Fisheries, and Food, London, England

    Professor F. A. Fairweather, Department of Health and Social Security,
         London, England (WHO Temporary Adviser)

    Dr M. Fujinaga, Federation of Food Additives Associations of Japan,
         Tokyo, Japan (FAO Temporary Adviser)

    Dr C. L. Galli, Department of Pharmacology and Pharmacognozy,
         University of Milan, Italy (WHO Temporary Adviser)

    Mr R. Haigh, Principal Administrator, Commission of European
         Communities, Brussels, Belgium (WHO Temporary Adviser)

    Dr G. D. Kouthon, Nutrition Officer, Food Policy and Nutrition
         Division, FAO, Rome, Italy (Joint Secretary)

    Dr L. Ladomery, Nutrition Officer, Food Standards, Food Policy and
         Nutrition Division, FAO, Rome, Italy

    Dr N. Rao Maturu, Nutrition Officer, Food Standards, Food Policy and
         Nutrition Division, FAO, Rome, Italy

    Dr P. Shubik, Director, Eppley Institute for Research in Cancer,
         University of Nebraska College of Medicine, Omaha, NE, United
         States of America (WHO Temporary Adviser)

    Dr S. A. Slorach, Toxicology Laboratory, Food Research Department,
         National Food Administration, Uppsala, Sweden (WHO Temporary
         Adviser)

    Dr G. Vettorazzi, Toxicologist - Food, International Programme on
         Chemical Safety, WHO, Geneva, Switzerland (Joint Secretary)





















    See Also:
       Toxicological Abbreviations