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        INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

        WORLD HEALTH ORGANIZATION



        TOXICOLOGICAL EVALUATION OF CERTAIN
        VETERINARY DRUG RESIDUES IN FOOD



        WHO FOOD ADDITIVES SERIES 23





        Prepared by:
        The 32th meeting of the Joint FAO/WHO Expert
        Committee on Food Additives (JECFA)



        World Health Organization, Geneva 1988


    (c) World Health Organization 1988

    First published 1988



    Printed in Great Britain at the University Press, Cambridge

    Library of Congress cataloguing in publication data available.

    British Library cataloguing in publication data
    Joint FAO/WHO Expert Committee on Food Additives.
    Meeting (32nd: 1987: Rome, Italy).
    Toxicological evaluation of certain veterinary drug residues in food.
    (WHO food additives series; 23).
    1.  Food. Additives & contaminants. Toxic effects.
    I.  Title  II. World Health Organization  III. Series

    ISBN 0 521 37916 4


    The preparation of this document was supported by the International
    Programme on Chemical Safety (IPCS), Geneve, Switzerland.


    CONTENTS

    Preface

         Chloramphenicol
         Trenbolone acetate
         Zeranol

    Annexes

         Annex 1    Reports and other documents resulting from
                    meetings of the Joint FAO/WHO Expert Committee
                    on Food Additives
         Annex 2    Abbreviations used in the monographs
         Annex 3    1987 JECFA participants
         Annex 4    Acceptable daily intakes, other toxicological
                    recommendations and information on specifications
    

    PREFACE

         The monographs contained in this volume were prepared by the
    thirty-second Joint FAO/WHO Expert Committee on Food Additives
    (JEFCA), which met in Rome, Italy, 15-23 June 1987. These monographs
    summarize the safety data on selected veterinary drug residues
    reviewed by the Committee. The data reviewed in these monographs form
    the basis for acceptable daily intakes (ADIs) established by the
    Committee.

         The thirty-second report of JECFA has been published by the World
    Health Organization as WHO Technical Report Series, No. 763. The
    participants in the meeting are listed in Annex 3 of the present
    publication and a summary of the conclusions of the Committee is
    included as Annex 4.

         Specifications established at the thirty-second meeting of JEFCA
    will be issued separately by FAO under the title, Specifications for
    the identity and purity of certain veterinary drug residues in the
    FAO Food and Nutrition Paper Series. These toxicological monographs
    should be read in conjunction with the specifications and the report.

         Reports and other documents resulting from previous meetings of
    the Joint FAO/WHO Expert Committee on Food Additives are listed in
    Annex 1.

         JEFCA serves as a scientific advisory body to FAO, WHO, their
    Member States, and the Codex Alimentarius Commission, primarily
    through the Codex Committee on Food Additives and the Codex Committee
    on Residues of Veterinary Drugs in Foods, regarding the safety of food
    additives, residues of veterinary drugs, and contaminants in food.
    Committees accomplish this task by preparing reports of their meetings
    and publishing specifications and toxicological monographs, such as
    those contained in this volume, on substances that they have
    considered.

         The toxicological monographs contained in this volume are based
    upon working papers that were prepared by temporary advisers in
    advance of the thirty-first JECFA meeting. A special acknowledgement
    is given to those who prepared these working papers, Dr S.
    Fitzpatrick, Center for Veterinary Medicine, Food and Drug
    Administration, Rockville, MD, USA; Dr C.L. Galli, Professor of
    Experimental Toxicology, University of Milan, Milan, Italy; Dr S.I.
    Shibko, Associate Director for Regulatory Evaluation, Center for Food
    Safety and Applied Nutrition, Food and Drug Administration,
    Washington, DC, USA; and Dr K.N. Woodward, Division of Toxicology and
    Environmental Protection, Department of Health and Social Security,
    London, England.

         Many proprietary unpublished reports are referenced. These were
    voluntarily submitted to the Committee by various producers of the
    veterinary drugs under review and in many cases these reports
    represent the only safety data available on these substances. The
    temporary advisers based the working papers they developed on all the
    data that were submitted, and all these studies were available to the
    Committee when it made its evaluations.

         From 1972 to 1975 the toxicology monographs prepared by Joint
    FAO/WHO Expert Committees on Food Additives were published in the WHO
    Food Additives Series; after 1975 this series became available only in
    the form of unpublished WHO documents provided upon request by the
    Organization. Beginning with the 1985 monographs, they are published
    by the Cambridge University Press, which should ensure that these
    monographs are more widely known and available.

         The preparation and editing of the monographs included in this
    volume have been made possible through the technical and financial
    contributions of the Participating Institutions of the International
    Programme on Chemical Safety (IPCS), which support the activities of
    JECFA. IPCS is a joint venture of the United Nations Environment
    Programme, the International Labour Organization, and the World Health
    Organization, which is the executing agency. One of the main
    objectives of the IPCS is to carry out and disseminate evaluations of
    the effects of chemicals on human health and the quality of the
    environment.

         The designations employed and the presentation of the material in
    this publication do not imply the expression of any opinion whatsoever
    on the part of the organizations participating in the IPCS concerning
    the legal status of any country, territory, city, or area or its
    authorities, or concerning the delimitation of its frontiers or
    boundaries. The mention of specific companies or of certain
    manufacturers' products does not imply that they are endorsed or
    recommended by those organizations in preference to others of a
    similar nature that are not mentioned.

         Any comments or new information on the biological or
    toxicological data on the compounds reported in this document should
    be addressed to: Joint WHO Secretary of the Joint FAO/WHO Expert
    Committee on Food Additives, International Programme on Chemical
    Safety, World Health Organization, Avenue Appia, 1211 Geneva 27,
    Switzerland.





















    See Also:
       Toxicological Abbreviations