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    ANNEX 2

    ABBREVIATIONS USED IN THE MONOGRAPHS

    AAF            2-acetylaminofluorene
    ADI            acceptable daily intake
    A/G            albumin/globulin ratio
    AIIBP          Association Internationale de L`Industrie des
                   Bouillons et Potages
    Alk-P-ase      alkaline phosphatase
    ALAT           alanine aminotransferase
    AMP            adenosine monophosphate
    ANFT           2-amino-(5-nitro-furyl)thiazole
    ASAT           aspartate aminotransferase
    ATP            adenosine triphosphate
    AUC            area under curve

    BBN            N-butyl-N-(-hydroxy- butyl)nitrosamine
    BHA            butylated hydroxyanisole
    BHT            butylated hydroxytoluene
    BSP            bromosulfophthalein
    BUN            blood urea nitrogen
    bw             body weight

    C              control group
    CFR            Code of Federal Regulations (USA)
    CGT            cyclodextrin glycosyl transferase
    CHO            Chinese hamster ovary
    CMC            carboxymethylcellulose
    Comm           Community
    cP             centipoise (viscosity measure)

    d              day
    D20            dose at which structural aberrations were detected in
                   20% of the metaphases observed
    DBCP           1,2-dibromo-3-chloropropane
    DEHP           di-[2-ethylhexyl]phthalate
    derm           dermal
    DiEHA          ethylhexanedioic acid
    Diff           differential leucocytes
    DMBA           7,12 dimethyl-1,2-benzanthracene
    DMH            1,2-dimethylhydrazine
    DNA            deoxyribonucleic acid
    Ds             Dunaliella salina
    dy             day

    EA             2-ethylhexanoic acid
    EC50           effective concentration, median
    EDA            ethylene diamine
    ED50           effective dose, median
    EEC            European Economic Community
    EHA            ethylhexanoic acid

    EH             2-Ethylhexanol
    EHEN           N-ethyl-N-hydroxy ethylnitrosamine
    EPA            Environmental Protection Agency (U.S.)
    Er             erythrocytes
    EROD           hepatic ethoxy-resorufin-O-deethylase
    ESR            erythrocyte sedimentation rate

    F              female
    F1             filial generation, first
    F2             filial generation, second
    FANFT          N-[-(5-nitro-2-furyl)-thiazolyl]formamide
    FAO            Food and Agriculture Organization of the United
                   Nations
    FBG            fasting blood glucose
    FEMA           Flavor and Extract Manufacturers' Association of the
                   United States
    FEP            free erythrocyte protoporphyrin

    GHB            glycosylated haemoglobin
    GI             gastrointestinal
    GIP            gastric inhibitory polypeptide
    GMP            Disodium 5'-guanylate (guanylic acid, disodium salt)
    G6Pase         glucose-6-phosphatase
    GRAS           food chemicals generally recognized as safe

    h              hour
    H              high dose
    Hb             haemoglobin
    HDL            high-density lipoprotein
    HDL-C          high-density lipoprotein cholesterol
    HeLa           Helen Lane
    HHS            Department of Health and Human Services (USA)
    HPF            high polyunsaturated fat
    HPLC           high performance liquid chromatography
    HSF            high saturated fat
    Hct            haematocrit

    IARC           International Agency for Research on Cancer
    IBT            Industrial Bio-Test Labs., Inc.
    ICG            indocyanine green
    ID50           inhibitory dose, 50%
    ID             iron deficiency
    IDA            iron deficiency anaemia
    im             intramuscular
    IMP            disodium 5'-inosinate
    inh            inhalation
    IPCS           International Programme on Chemical Safety
    ip             intraperitoneal
    IRDC           International Research and Development Corporation
    iv             intravenous

    JECFA          Joint FAO/WHO Expert Committee on Food Additives

    KM             konjac flour, konjac mannan

    L              low dose
    LD50           lethal dose, median
    LDH            lactate dehydrogenase
    LDL-C          low-density lipoprotein cholesterol
    LDLO           lethal dose, lowest
    Leu            leucocytes
    LF             low fat

    m              male
    MCHC           mean corpuscular haemoglobin concentration
    3-MCPD         3-chloro-1,2-propanediol (3-monochloropropane-1,2-
                   diol)
    MCV            mean cell volume
    MEHP           mono-[2-ethylhexyl]phthalate
    MFO            mixed function oxidase
    mg             milligram
    min            minute
    MNNG           N-methyl-N-nitrosoguanidine
    MNU            methyl-N-nitrosourea
    MRI            Midwest Research Institute
    MSG            monosodium glutamate
    MTD            maximum tolerated dose
    mU             1/1000 International Unit insulin, 1 IU=0.04167 mg of
                   international standard preparation

    NaFeEDTA       sodium iron EDTA
    NBR            NCI-Black-Reiter (rats)
    NEL            no-effect-level
    NOAEL          no-observed-adverse-effect-level
    NOEL           no-observed-effect level
    NQO            nitroquinoline oxide
    NTP            National Toxicology Program (USA)

    OCT            ornithine carbamyl transferase
    ODC            ornithine decarboxylase
    5-OH EHA       5-hydroxyethylhexanoic acid

    PAS            periodic acid Shiff
    PBG            2-hour post-prandial blood glucose
    pc             percutaneous
    PCV            packed red cell volume
    PG             propyl gallate
    PGA            propylene glycol alginate
    PN             papillary or nodular hyperplasia
    PNG            Phillipines natural grade [carrageenan]
    po             by mouth
    ppm            parts per million
    PSP            phenosulfophthalein
    RNA            ribonucleic acid

    RTP            Research Triangle Park, NC (USA)

    SAIB           sucrose acetate isobutyrate
    SAP            serum alkaline phosphatase
    % Sat          % Saturation of Transferrin
    s.c.           subcutaneous(ly)
    SCF            soya-bean cotyledon fiber
    SER            smooth endoplasmic reticulum
    SHADIB         sucrose hexaacetate diisobutyrate
    SLRL           sex-linked recessive lethal
    SOIB           sucrose octaisobutyrate

    t             half-life
    TBHQ           tertiary butylhydroquinone
    TC             total cholesterol
    TG             triglyceride
    TR             frequency of cells with exchange type aberrations per
                   unit dose (mg/ml)

    USEPA          United States Environmental Protection Agency

    v/v            volume/volume

    WBC            white blood cell
    WHO            World Health Organization





















    See Also:
       Toxicological Abbreviations