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    INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

    WORLD HEALTH ORGANIZATION



    TOXICOLOGICAL EVALUATION OF CERTAIN 
    VETERINARY DRUG RESIDUES IN FOOD



    WHO FOOD ADDITIVES SERIES 45





    Prepared by the
    Fifty-fourth meeting of the Joint FAO/WHO
    Expert Committee on Food Additives (JECFA)



    World Health Organization, Geneva, 2000

    This publication is a contribution to the International Programme on
    Chemical Safety.

    The International Programme on Chemical Safety (IPCS), established in
    1980, is a joint venture of the United Nations Environment Programme
    (UNEP), the International Labour Organisation (ILO), and the World
    Health Organization (WHO). The overall objectives of the IPCS are to
    establish the scientific basis for assessing the risk to human health
    and the environment from exposure to chemicals, through international
    peer-review processes, as a prerequisite for the promotion of chemical
    safety, and to provide technical assistance in strengthening national
    capacities for the sound management of chemicals.

    The Inter-Organization Programme for the Sound Management of Chemicals
    (IOMC) was established in 1995 by UNEP, ILO, the Food and Agriculture
    Organization of the United Nations, WHO, the United Nations Industrial
    Development Organization, and the Organisation for Economic
    Co-operation and Development (Participating Organizations), following
    recommendations made by the 1992 United Nations Conference on
    Environment and Development to strengthen cooperation and increase
    coordination in the field of chemical safety. The purpose of the IOMC
    is to promote coordination of the policies and activities pursued by
    the Participating Organizations, jointly or separately, to achieve the
    sound management of chemicals in relation to human health and the
    environment.

    Health & Environment International, Ltd, by agreement with WHO,
    performed independent literature searches on some of the substances on
    which data are summarized in this document in order to ensure that all
    relevant toxicological and related information was reviewed.

    ISBN 92 4 166045 7

    CONTENTS

    Preface 

    Antimicrobial agent: Lincomycin

    Insecticides 
         Cyhalothrin
         Dicyclanil 
         Trichlorfon

    Production aid: Melengestrol acetate

    Annexes 
         Annex 1   Reports and other documents resulting from previous
                   meetings of the Joint FAO/WHO Expert Committee on Food
                   Additives
         Annex 2   Abbreviations used in the monographs
         Annex 3   Participants in the fifty-fourth meeting of the Joint
                   FAO/WHO Expert Committee on Food Additives
         Annex 4   Recommendations on compounds on the agenda and further
                   toxicological studies and information required 
    

    PREFACE

         The monographs contained in this volume were prepared at the
    fifty-fourth meeting of the Joint FAO/WHO Expert Committee on Food
    Additives (JECFA), which met at WHO Headquarters in Geneva,
    Switzerland, 15-24 February 2000. These monographs summarize the
    safety data on the residues in food of selected veterinary drugs
    reviewed by the Committee.

         The fifty-fourth report of JECFA will be published by the World
    Health Organization in the WHO Technical Report Series. Reports and
    other documents resulting from previous meetings of JECFA are listed
    in Annex 1. The participants in the meeting are listed in Annex 3 of
    the present publication; a summary of the conclusions of the Committee
    is given in Annex 4. 

         Monographs on residues of the veterinary drugs that were
    evaluated at the fifty-fourth meeting of JECFA will be issued
    separately by FAO as Food and Nutrition Paper No. 41/13. The
    toxicological monographs in the present publication should be read in
    conjunction with the residues monographs and the report.

         JECFA serves as a scientific advisory body to FAO, WHO, their
    Member States, and the Codex Alimentarius Commission, primarily
    through the Codex Committee on Food Additives and Contaminants and the
    Codex Committee on Residues of Veterinary Drugs in Foods, regarding
    the safety of food additives, residues of veterinary drugs, naturally
    occurring toxicants, and contaminants in food. Committees accomplish
    this task by preparing reports of their meetings and publishing
    specifications or residue monographs and toxicological monographs,
    such as those contained in this volume, on substances that they have
    considered. 

         The toxicological monographs contained in this volume are based
    upon working papers that were prepared by Temporary Advisers. A
    special acknowledgement is given at the beginning of each monograph to
    those who prepared these working papers.

         Many proprietary unpublished reports are referenced. These were
    voluntarily submitted to the Committee by various producers of the
    veterinary drugs under review and in many cases represent the only
    data on safety available on those substances. The Temporary Advisers
    based the working papers they developed on all of the data that were
    submitted, and all of these reports were available to the Committee
    when it made its evaluations. The monographs were edited by E.
    Heseltine, Lajarthe, 24290 St Léon-sur-Vézère, France.

         The preparation and editing of the monographs included in this
    volume were made possible through the technical and financial
    contributions of the Participating Organizations of the International
    Programme on Chemical Safety (IPCS), which supports the activities of
    JECFA.

         The designations employed and the presentation of the material in
    this publication do not imply the expression of any opinion whatsoever
    on the part of the organizations participating in the IPCS concerning
    the legal status of any country, territory, city, or area or its
    authorities, or concerning the delimitation of its frontiers or
    boundaries. The mention of specific companies or of certain
    manufacturers' products does not imply that they are endorsed or
    recommended by those organizations in preference to others of a
    similar nature that are not mentioned.

         Any comments or new information on the biological or
    toxicological properties of the compounds evaluated in this
    publication should be addressed to: Joint WHO Secretary of the Joint
    FAO/WHO Expert Committee on Food Additives, International Programme on
    Chemical Safety, World Health Organization, Avenue Appia, 1211 Geneva
    27, Switzerland.





















    See Also:
       Toxicological Abbreviations